Urinary markers of disease activity in multiple sclerosis

被引:11
作者
Giovannoni, G [1 ]
Thompson, EJ [1 ]
机构
[1] Inst Neurol, Dept Clin Neurol & Neurochem, London WC1N 3BG, England
来源
MULTIPLE SCLEROSIS | 1998年 / 4卷 / 03期
关键词
multiple sclerosis; urine; neopterin;
D O I
10.1191/135245898678909321
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Numerous markers of disease activity, representing different aspects of the inflammatory cascade and pathogenic process in multiple sclerosis, con be detected in the urine. Urinary monitoring provides distinct advantages over blood and cerebrospinal fluid: it is easier to collect allows frequent sampling and acts as a natural integrator by capturing the excretion of a substance over a prolonged Period of time. We will discuss the principles, advantages, and pitfalls of urinary monitoring in relationship to multiple sclerosis.
引用
收藏
页码:247 / 253
页数:7
相关论文
共 31 条
[1]  
Allen IV, 1991, MCALPINES MULTIPLE S, P341
[2]   CIRCADIAN-RHYTHM OF SERUM INTERLEUKIN-6 IN RHEUMATOID-ARTHRITIS [J].
ARVIDSON, NG ;
GUDBJORNSSON, B ;
ELFMAN, L ;
RYDEN, AC ;
TOTTERMAN, TH ;
HALLGREN, R .
ANNALS OF THE RHEUMATIC DISEASES, 1994, 53 (08) :521-524
[3]  
AUZEBY A, 1988, CLIN CHEM, V34, P1866
[4]  
BANNISTER KM, 1996, OXFORD TXB MED, V3, P3101
[5]   Sequential monitoring of urine-soluble interleukin 2 receptor and interleukin 6 predicts acute rejection of human renal allografts before clinical or laboratory signs of renal dysfunction [J].
Casiraghi, F ;
Ruggenenti, P ;
Noris, M ;
Locatelli, G ;
Perico, N ;
Perna, A ;
Remuzzi, G .
TRANSPLANTATION, 1997, 63 (10) :1508-1514
[6]   Determination of beta(2)-microglobulin in human serum and urine by latex turbidimetry [J].
Gella, FJ ;
Capdevila, MJ .
PURE AND APPLIED CHEMISTRY, 1996, 68 (10) :1881-1885
[7]  
GIOVANNONI C, 1997, ANN CLIN BIOCHEM, V34, P193
[8]   Daily urinary neopterin excretion as an immunological marker of disease activity in multiple sclerosis [J].
Giovannoni, G ;
Lai, M ;
Kidd, D ;
Thorpe, JW ;
Miller, DH ;
Thompson, AJ ;
Keir, G ;
Feldmann, M ;
Thompson, EJ .
BRAIN, 1997, 120 :1-13
[9]  
HARTMANN AE, 1994, CLIN LAB MED, P371
[10]   THE CLINICAL RELEVANCE OF LOCALLY PRODUCED CARCINOEMBRYONIC ANTIGEN IN CEREBROSPINAL-FLUID [J].
JACOBI, C ;
REIBER, H ;
FELGENHAUER, K .
JOURNAL OF NEUROLOGY, 1986, 233 (06) :358-361