Mild Three-Step Consecutive C-H Activations

被引：8
作者：
Liu, Yao-Yao [1 ]
Qu, Yuan-Lu [1 ]
Kang, Yan-Shang [1 ]
Zhu, Yue-Lu [1 ]
Sun, Wei-Yin [1 ]
Lu, Yi [1 ]
机构：
[1] Nanjing Univ, Collaborat Innovat Ctr Adv Micro Struct, Nanjing Natl Lab Microstruct,Sch Chem & Chem Engn, Coordinat Chem Inst,State Key Lab Coordinat Chem, Nanjing 210023, Peoples R China
来源：
ORGANIC LETTERS | 2022年 / 24卷 / 17期
基金：
中国国家自然科学基金;
关键词：
OXIDATIVE OLEFINATION; ALKYNES; FUNCTIONALIZATION; ANNULATION; ALKENES; ACIDS; RH;
D O I：
10.1021/acs.orglett.2c00620
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, the Rh-catalyzed consecutive C-Hbondolefination/annulation/olefination cascade, tandemly directed bysulfonamide and ester groups, has been developed under mildconditions with the assistance of 1-adamantane carboxylic acid. Aseven-membered metallacycle including an ester group was preferredto thefive-membered one including a sulfonamide group for the thirdC-H activation. In this transformation, the Rh catalyst exhibits its highreactivity by catalyzing a triple C-H activation process with a low catalyst loading at 50 degrees C. This method can be applied in theconstruction of various pharmaceutical derivatives.
引用
收藏
页码：3118 / 3122
页数：5
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