Mild Three-Step Consecutive C-H Activations

被引：8

作者：

Liu, Yao-Yao ^{[1
]}

Qu, Yuan-Lu ^{[1
]}

Kang, Yan-Shang ^{[1
]}

Zhu, Yue-Lu ^{[1
]}

Sun, Wei-Yin ^{[1
]}

Lu, Yi ^{[1
]}

机构：

[1] Nanjing Univ, Collaborat Innovat Ctr Adv Micro Struct, Nanjing Natl Lab Microstruct,Sch Chem & Chem Engn, Coordinat Chem Inst,State Key Lab Coordinat Chem, Nanjing 210023, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 17期

基金：

中国国家自然科学基金;

关键词：

OXIDATIVE OLEFINATION; ALKYNES; FUNCTIONALIZATION; ANNULATION; ALKENES; ACIDS; RH;

D O I：

10.1021/acs.orglett.2c00620

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, the Rh-catalyzed consecutive C-Hbondolefination/annulation/olefination cascade, tandemly directed bysulfonamide and ester groups, has been developed under mildconditions with the assistance of 1-adamantane carboxylic acid. Aseven-membered metallacycle including an ester group was preferredto thefive-membered one including a sulfonamide group for the thirdC-H activation. In this transformation, the Rh catalyst exhibits its highreactivity by catalyzing a triple C-H activation process with a low catalyst loading at 50 degrees C. This method can be applied in theconstruction of various pharmaceutical derivatives.

引用

页码：3118 / 3122

页数：5

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