Tumor clinicopathological characteristics and their prognostic value in mucinous colorectal carcinoma

被引：3
作者：
Luo, Cong [1 ]
Cen, Shuyi [2 ]
Ying, Jieer [1 ]
Wang, Xiaohong [1 ]
Fu, Zhixuan [3 ]
Liu, Peng [4 ]
Wu, Wei [5 ]
Ding, Guojun [4 ]
机构：
[1] Chinese Acad Sci, Univ Chinese Acad Sci, Inst Canc Res & Basic Med Sci, Canc Hosp,Zhejiang Canc Hosp,Dept Abdominal Oncol, Hangzhou 310022, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China
[3] Chinese Acad Sci, Univ Chinese Acad Sci, Inst Canc Res & Basic Med Sci, Canc Hosp,Zhejiang Canc Hosp,Dept Colorectal Surg, Hangzhou 310022, Zhejiang, Peoples R China
[4] Chinese Acad Sci, Univ Chinese Acad Sci, Inst Canc Res & Basic Med Sci, Canc Hosp,Zhejiang Canc Hosp,Dept Radiotherapy, Hangzhou 310022, Zhejiang, Peoples R China
[5] Chinese Acad Sci, Univ Chinese Acad Sci, Inst Canc Res & Basic Med Sci, Canc Hosp,Zhejiang Canc Hosp,Dept Pathol, Hangzhou 310022, Zhejiang, Peoples R China
来源：
FUTURE ONCOLOGY | 2019年 / 15卷 / 35期
关键词：
appendix; chemotherapy; colorectal cancer; mucinous adenocarcinoma; pathology; postoperative; prognosis; risk factors; tumor characteristics; HISTOLOGY PREDICTS; CANCER; SURVIVAL; COLON; ADENOCARCINOMA; EXPRESSION; STAGE; DIFFERENTIATION; CHEMOTHERAPY;
D O I：
10.2217/fon-2019-0342
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: This study analyzed clinicopathological features of colorectal mucinous carcinoma and their prognostic values. Patients & method: This study enrolled 265 patients with mucinous colorectal cancer. Clinicopathological information and prognosis were reviewed retrospectively. Kaplan-Meier method, log- rank test and COX proportional hazard regression models were used. Results: In postoperative mucinous carcinoma patients (median age 56, 119 [44.9%] female), advanced tumor stage (odds ratio [OR]: 2.378; 95% CI: 1.512-3.741; p = 0.0002), poor differentiation (OR: 1.896; CI: 1.217-2.955; p = 0.0047) and right-sided tumors (OR: 2.421; CI: 1.145-5.102; p = 0.0206) were associated with shorter overall survival. Appendiceal/ileocecal cecal tumors were not different for prognosis. Conclusion: Mucinous colorectal carcinoma exhibits distinct tumor characteristics. Poor differentiation, advanced stage at presentation and the right side serve as negative prognostic factors.
引用
收藏
页码：4095 / 4104
页数：10
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