Access to optically active 2,2′-dihydroxy-6,6′-dimethoxy-1,1′-biphenyl by a simple biocatalytic procedure

被引：18

作者：

Sanfilippo, C

Nicolosi, G

Delogu, G

Fabbri, D

Dettori, MA

机构：

[1] CNR, Ist Chim Biomol, Sez Catania, I-95028 Valverde, CT, Italy

[2] CNR, Ist Chim Biomol, Sez Sassari, I-07040 Sassari, Italy

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 21期

关键词：

ASYMMETRIC-SYNTHESIS; KINETIC RESOLUTION; DESYMMETRIZATION; CHEMISTRY; BIARYL; 2,2',6,6'-TETRAHYDROXYBIPHENYL; REDUCTION; BIPHENYL; KETONES; ESTERS;

D O I：

10.1016/j.tetasy.2003.08.002

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Lipase from Pseudomonas cepacia was found to catalyze acetylation in tert-butyl methyl ether of the title alcohol 1. The action of four different P. cepacia preparations was compared, all possessing high steric recognition, that results in an efficient kinetic resolution of this atropisomeric biphenyl. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3267 / 3270

页数：4

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