Flexible, high-resolution thin-film electrodes for human and animal neural research

被引：27

作者：

Chiang, Chia-Han ^{[1
]}

Wang, Charles ^{[1
]}

Barth, Katrina ^{[1
]}

Rahimpour, Shervin ^{[2
]}

Trumpis, Michael ^{[1
]}

Duraivel, Suseendrakumar ^{[1
]}

Rachinskiy, Iakov ^{[1
]}

Dubey, Agrita ^{[3
]}

Wingel, Katie E. ^{[3
]}

Wong, Megan ^{[1
]}

Witham, Nicholas S. ^{[4
,5
]}

Odell, Thomas ^{[5
]}

Woods, Virginia ^{[1
]}

Bent, Brinnae ^{[1
]}

Doyle, Werner ^{[6
]}

Friedman, Daniel ^{[7
]}

Bihler, Eckardt ^{[8
]}

Reiche, Christopher F. ^{[4
]}

Southwell, Derek G. ^{[2
]}

Haglund, Michael M. ^{[2
]}

Friedman, Allan H. ^{[2
]}

Lad, Shivanand P. ^{[2
]}

Devore, Sasha ^{[7
]}

Devinsky, Orrin ^{[6
,7
,9
]}

Solzbacher, Florian ^{[4
,5
,10
]}

Pesaran, Bijan ^{[3
,7
]}

Cogan, Gregory ^{[2
,12
,13
,14
]}

Viventi, Jonathan ^{[1
,2
,11
,14
]}

机构：

[1] Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA

[2] Duke Sch Med, Dept Neurosurg, Durham, NC 27710 USA

[3] NYU, Ctr Neural Sci, New York, NY 10003 USA

[4] Univ Utah, Dept Elect & Comp Engn, Salt Lake City, UT USA

[5] Univ Utah, Dept Biomed Engn, Salt Lake City, UT USA

[6] NYU, Dept Neurosurg, Langone Med Ctr, 550 1St Ave, New York, NY 10016 USA

[7] NYU, Grossman Sch Med, Dept Neurol, New York, NY 10003 USA

[8] DYCONEX AG, Bassersdorf, Switzerland

[9] NYU Langone Hlth, Comprehens Epilepsy Ctr, New York, NY USA

[10] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA

[11] Duke Sch Med, Dept Neurobiol, Durham, NC 27710 USA

[12] Duke Univ, Dept Psychol & Neurosci, Durham, NC 27708 USA

[13] Duke Univ, Ctr Cognit Neurosci, Durham, NC 27708 USA

[14] Duke Sch Med, Duke Comprehens Epilepsy Ctr, Durham, NC 27710 USA

来源：

JOURNAL OF NEURAL ENGINEERING | 2021年 / 18卷 / 04期

关键词：

intraoperative; ECoG; electrode; iEEG; LCP; Brain Machine Interface (BMI); Neural Interface; HIGH-FREQUENCY OSCILLATIONS; LOCAL-FIELD POTENTIALS; LONG-TERM; GAMMA OSCILLATIONS; TEMPORAL-LOBE; EPILEPSY; BRAIN; MICROSEIZURES; STIMULATION; MOVEMENTS;

D O I：

10.1088/1741-2552/ac02dc

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Objective. Brain functions such as perception, motor control, learning, and memory arise from the coordinated activity of neuronal assemblies distributed across multiple brain regions. While major progress has been made in understanding the function of individual neurons, circuit interactions remain poorly understood. A fundamental obstacle to deciphering circuit interactions is the limited availability of research tools to observe and manipulate the activity of large, distributed neuronal populations in humans. Here we describe the development, validation, and dissemination of flexible, high-resolution, thin-film (TF) electrodes for recording neural activity in animals and humans. Approach. We leveraged standard flexible printed-circuit manufacturing processes to build high-resolution TF electrode arrays. We used biocompatible materials to form the substrate (liquid crystal polymer; LCP), metals (Au, PtIr, and Pd), molding (medical-grade silicone), and 3D-printed housing (nylon). We designed a custom, miniaturized, digitizing headstage to reduce the number of cables required to connect to the acquisition system and reduce the distance between the electrodes and the amplifiers. A custom mechanical system enabled the electrodes and headstages to be pre-assembled prior to sterilization, minimizing the setup time required in the operating room. PtIr electrode coatings lowered impedance and enabled stimulation. High-volume, commercial manufacturing enables cost-effective production of LCP-TF electrodes in large quantities. Main Results. Our LCP-TF arrays achieve 25x higher electrode density, 20x higher channel count, and 11x reduced stiffness than conventional clinical electrodes. We validated our LCP-TF electrodes in multiple human intraoperative recording sessions and have disseminated this technology to >10 research groups. Using these arrays, we have observed high-frequency neural activity with sub-millimeter resolution. Significance. Our LCP-TF electrodes will advance human neuroscience research and improve clinical care by enabling broad access to transformative, high-resolution electrode arrays.

引用

页数：17

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