Stereoselective synthesis of 3,3-diarylacrylonitriles as tubulin polymerization inhibitors

被引：19

作者：

Fang, Zhenglai ^{[1
,2
]}

Song, Yunlong ^{[1
,2
]}

Sarkar, Taradas ^{[3
]}

Hamel, Ernest ^{[3
]}

Fogler, William E. ^{[4
]}

Agoston, Gregory E. ^{[4
]}

Fanwick, Phillip E. ^{[5
]}

Cushman, Mark ^{[1
,2
]}

机构：

[1] Purdue Univ, Sch Pharm & Pharmaceut Sci, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA

[2] Purdue Univ, Purdue Canc Ctr, W Lafayette, IN 47907 USA

[3] Natl Inst Hlth, Natl Canc Inst, Div Canc Treatment & Diag, Dev Therapeut Program,Toxicol & Pharmacol Branch, Frederick, MD 21702 USA

[4] EntreMed Inc, Rockville, MD 20850 USA

[5] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 11期

关键词：

D O I：

10.1021/jo800428b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 3,3-diarylacrylonitriles were synthesized stercoselectively as tubulin polymerization inhibitors for potential use in cancer chemotherapy. This synthetic route features stannylcupration and palladium-catalyzed Stille cross-coupling chemistry, allowing both E and Z isomers of 3,3-diarylacrylonitriles to be prepared in a very short sequence of reactions.

引用

页码：4241 / 4244

页数：4

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