Brugada Syndrome: Progress in Genetics, Risk Stratification and Management

被引：6

作者：

Romero, Jorge ^{[1
]}

Li, Dan L. ^{[1
,2
]}

Avendano, Ricardo ^{[1
,3
]}

Diaz, Juan Carlos ^{[1
]}

Tung, Roderick ^{[4
]}

Di Biase, Luigi ^{[1
]}

机构：

[1] Montefiore Med Ctr, Albert Einstein Coll Med, Bronx, NY 10467 USA

[2] Vanderbilt Univ, Med Ctr, Dept Med, Cardiovasc Div, Nashville, TN USA

[3] Yale Univ, Sch Med, Dept Internal Med, Sect Cardiovasc Med, New Haven, CT 06510 USA

[4] Univ Chicago, Sch Med, Chicago, IL 60637 USA

来源：

ARRHYTHMIA & ELECTROPHYSIOLOGY REVIEW | 2019年 / 8卷 / 01期

关键词：

Brugada syndrome; epicardial ablation; genetic testing; radiofrequency ablation; risk stratification; IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR; PROGRAMMED ELECTRICAL-STIMULATION; EPICARDIAL SUBSTRATE ABLATION; PREVIOUS CARDIAC-ARREST; LONG-TERM PROGNOSIS; VENTRICULAR-FIBRILLATION; CATHETER ABLATION; SODIUM CURRENT; SUDDEN-DEATH; PREVENTION;

D O I：

10.15420/aer.2018.66.2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Brugada syndrome (BrS) is one of the most common causes of sudden cardiac death in normal structural heart individuals. First characterised in 1992, the global prevalence of BrS is unclear, with estimates placing it at around 0.05% and presenting most frequently in southeast Asian countries. This review aims to summarise the development in the understanding of BrS and, importantly, progress in its management, underpinned by knowledge regarding its genetics and molecular mechanisms. It also provides update on risk stratification and promising new therapies for BrS, including epicardial ablation. Future studies are required to increase understanding of the pathogenesis of this disease and to guide clinical practice.

引用

页码：19 / 27

页数：9

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