Development of a Glassy Carbon Electrode Modified with Graphene/Au Nanoparticles for Determination of Acetaminophen in Pharmaceutical Preparation

被引：12

作者：

Wei, Yingliang ^{[1
]}

Wang, Anting ^{[1
]}

Liu, Yuanyuan ^{[1
]}

机构：

[1] Luoyang Inst Sci & Technol, Sch Environm Engn & Chem, Luoyang 471023, Peoples R China

来源：

RUSSIAN JOURNAL OF ELECTROCHEMISTRY | 2018年 / 54卷 / 12期

关键词：

acetaminophen; grapheme; Au nano-particle; voltammetry; HUMAN PLASMA; PARACETAMOL; OXIDATION;

D O I：

10.1134/S1023193518140112

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

A graphene/Au nanoparticles composite modified glassy carbon electrode (GR/AuNPs/GCE) was developed. Electrochemical behavior of acetaminophen (ACOP) at this modified electrode was studied by liner sweep voltammetry (LSV) in pH 6.0 phosphate buffer solution. The effect factors of the electrochemical response of ACOP were optimized by LSV. Under the optimum conditions, a linear calibration curve of the oxidation peak current of ACOP and concentration was obtained in the range of 1.0 x 10(-6) to similar to 2.2x10(-4) M. The peak current increases linearly with the scan rate, indicating that the reaction of ACOP at the modified electrode is adsorption-controlled process. This new proposed method has been successfully employed to determine acetaminophen in pharmaceutical preparation.

引用

页码：1141 / 1147

页数：7

共 24 条

[1] Simultaneous electrochemical determination of dopamine and acetaminophen using multiwall carbon nanotubes modified glassy carbon electrode [J].

Alothman, Zeid Abdullah ;

Bukhari, Nausheen ;

Wabaidur, Saikh Mohammad ;

Haider, Sajjad .

SENSORS AND ACTUATORS B-CHEMICAL, 2010, 146 (01) :314-320

[2] A Sensor for Simultaneous Determination of Acetaminophen and Codeine at Glassy Carbon Electrode Modified with Multi-Walled Carbon Nanotubes [J].

Babaei, Ali ;

Dehdashti, Aliyeh ;

Afrasiabi, Mohammad ;

Babazadeh, Mitra ;

Farshbaf, Mojtaba ;

Bamdad, Farzad .

SENSOR LETTERS, 2012, 10 (3-4) :1039-1046

[3] Ultrathin epitaxial graphite: 2D electron gas properties and a route toward graphene-based nanoelectronics [J].

Berger, C ;

Song, ZM ;

Li, TB ;

Li, XB ;

Ogbazghi, AY ;

Feng, R ;

Dai, ZT ;

Marchenkov, AN ;

Conrad, EH ;

First, PN ;

de Heer, WA .

JOURNAL OF PHYSICAL CHEMISTRY B, 2004, 108 (52) :19912-19916

[4] Paracetamol (acetaminophen)-induced toxicity: Molecular and biochemical mechanisms, analogues and protective approaches [J].

Bessems, JGM ;

Vermeulen, NPE .

CRITICAL REVIEWS IN TOXICOLOGY, 2001, 31 (01) :55-138

[5] Determination of acetaminophen by electrochemical co-deposition of glutamic acid and gold nanoparticles [J].

Bui, Minh-Phuong Ngoc ;

Li, Cheng Ai ;

Han, Kwi Nam ;

Pham, Xuan-Hung ;

Seong, Gi Hun .

SENSORS AND ACTUATORS B-CHEMICAL, 2012, 174 :318-324

[6] Fast determination of paracetamol by using a very simple photometric flow-through sensing device [J].

Cañada, MJA ;

Reguera, MIP ;

Medina, AR ;

de Córdova, MLF ;

Díaz, AM .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2000, 22 (01) :59-66

[7] An Electrochemical Approach to Simultaneous Determination of Acetaminophen and Ofloxacin [J].

Chen, Te-San ;

Huang, Kuo-Lin ;

Chen, Jia-Long .

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 2012, 89 (06) :1284-1288

[8] Electrochemistry and voltammetric determination of L-tryptophan and L-tyrosine using a glassy carbon electrode modified with a Nafion/TiO2-graphene composite film [J].

Fan, Yang ;

Liu, Jin-Hang ;

Lu, Hai-Ting ;

Zhang, Qin .

MICROCHIMICA ACTA, 2011, 173 (1-2) :241-247

[9] The rise of graphene [J].

Geim, A. K. ;

Novoselov, K. S. .

NATURE MATERIALS, 2007, 6 (03) :183-191

[10] Graphene: Synthesis, Functionalization and Applications in Chemistry [J].

Hu Yao-Juan ;

Jin Juan ;

Zhang Hui ;

Wu Ping ;

Cai Chen-Xin .

ACTA PHYSICO-CHIMICA SINICA, 2010, 26 (08) :2073-2086

← 1 2 3 →