Biologically Active C-Alkylated Flavonoids from Dodonaea viscosa

被引：45

作者：

Muhammad, Akhtar ^{[1
]}

Anis, Itrat ^{[1
]}

Khan, Ajmal ^{[2
]}

Marasini, Bishnu P. ^{[2
]}

Choudhary, Muhammad Iqbal ^{[2
]}

Shah, Muhammad Raza ^{[2
]}

机构：

[1] Univ Karachi, Dept Chem, Karachi 75270, Pakistan

[2] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2012年 / 35卷 / 03期

关键词：

Dodonaea viscosa; Spindaceae; Flavonoid; Urease and alpha-chymotrypsin enzymes; INHIBITORY CONSTITUENTS; ANTIBACTERIAL ACTIVITIES; AMBERBOA-RAMOSA; DURANTA-REPENS; NEPETA-SUAVIS; PEPTIC ULCER; ANTIFUNGAL; CHYMOTRYPSIN; TRITERPENE; DITERPENE;

D O I：

10.1007/s12272-012-0305-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new C-alkylated flavonoid (5,7-dihydroxy-3'-(4 ''-acetoxy-3 ''-methylbutyl)-3,6,4'-trimethoxyflavone (1), along with two known C-alkylated flavonoids (5,7-dihydroxy-3'-(3-hydroxymethyl-butyl)-3,6,4'-trimethoxyflavone (2), 5,7,4'-trihydroxy-3'-(3-hyroxymethylbutyl)-3,6-dimethoxyflavone (3) and two new source C-alkylated flavonoids (5,7-dihydroxy-3'-(2-hydroxy-3-methyl-3-butenyl)-3,6,4'-trimethoxyflavone (4), 5,7,4'-trihydroxy-3,6-dimethoxy-3'-isoprenyl-flavone (5) were isolated from the aerial parts of Dodonaea viscosa. The structures of all compounds were established on the basis of 1D and 2D NMR spectroscopy and mass spectrometry. The isolated compounds were evaluated for their inhibitory effect on urease and alpha-chymotrypsin enzyme. All the compounds (1-5) exhibited mild inhibition against urease but remained recessive in case of alpha-chymotrypsin.

引用

页码：431 / 436

页数：6

共 30 条

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