Ag2 and Ag3 Clusters: Synthesis, Characterization, and Interaction with DNA

被引：61

作者：

Buceta, David ^{[1
]}

Busto, Natalia ^{[2
]}

Barone, Giampaolo ^{[3
]}

Leal, Jose M. ^{[2
]}

Dominguez, Fernando ^{[4
,5
]}

Giovanetti, Lisandro J. ^{[6
]}

Requejo, Felix G. ^{[6
]}

Garcia, Begona ^{[2
]}

Arturo Lopez-Quintela, M. ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Dept Phys Chem, Santiago De Compostela 15782, Spain

[2] Univ Burgos, Dept Chem, Burgos 9001, Spain

[3] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, I-90128 Palermo, Italy

[4] Univ Santiago de Compostela, Dept Physiol, Santiago De Compostela 15782, Spain

[5] Univ Santiago de Compostela, Ctr Invest Med Mol & Enfermedades Cron CIMUS, Santiago De Compostela 15782, Spain

[6] Univ Nacl La Plata, CONICET, Inst Invest Fis Quim Teor & Aplicadas INIFTA, RA-1900 La Plata, Argentina

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 26期

关键词：

cluster compounds; DNA; electrochemical synthesis; intercalation; silver; SILVER; BINDING; MECHANISM; INTERCALATION; NANOPARTICLES; FLUOROPHORES; NANOCLUSTERS; HELIX; MODE; GOLD;

D O I：

10.1002/anie.201502917

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Subnanometric samples, containing exclusively Ag-2 and Ag-3 clusters, were synthesized for the first time by kinetic control using an electrochemical technique without the use of surfactants or capping agents. By combination of thermodynamic and kinetic measurements and theoretical calculations, we show herein that Ag-3 clusters interact with DNA through intercalation, inducing significant structural distortion to the DNA. The lifetime of Ag-3 clusters in the intercalated position is two to three orders of magnitude longer than for classical organic intercalators, such as ethidium bromide or proflavine.

引用

页码：7612 / 7616

页数：5

共 30 条

[1] Influence of cyanine dye structure on self-aggregation and interaction with nucleic acids: A kinetic approach to TO and BO binding [J].