No association of brain-derived neurotrophic factor Val66Met polymorphism with anorexia nervosa in Japanese

被引：14

作者：

Ando, Tetsuya ^{[1
]}

Ishikawa, Toshio ^{[2
]}

Hotta, Mari ^{[3
]}

Naruo, Tetsuro ^{[4
]}

Okabe, Kenjiro ^{[5
]}

Nakahara, Toshihiro ^{[6
]}

Takii, Masato ^{[7
]}

Kawai, Keisuke ^{[7
]}

Mera, Takashi ^{[8
]}

Nakamoto, Chiemi ^{[9
]}

Takei, Michiko ^{[10
]}

Yamaguchi, Chikara ^{[11
]}

Nagata, Toshihiko ^{[12
]}

Okamoto, Yuri ^{[13
]}

Ookuma, Kazuyoshi ^{[14
]}

Koide, Masanori ^{[15
]}

Yamanaka, Takao ^{[16
]}

Murata, Shiho ^{[17
]}

Tamura, Naho ^{[2
]}

Kiriike, Nobuo ^{[12
]}

Ichimaru, Yuhei ^{[18
]}

Komaki, Gen ^{[1
]}

机构：

[1] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Psychosomat Res, Kodaira, Tokyo 1878553, Japan

[2] Kohnodai Hosp, Int Med Ctr Japan, Dept Body Mind Med, Ichikawa, Chiba, Japan

[3] Natl Grad Inst Policy Studies, Hlth Serv Ctr, Minato Ku, Tokyo, Japan

[4] Nogami Hosp, Dept Psychosomat Med, Kagoshima, Japan

[5] Tenri Hosp, Dept Psychosomat Med, Tenri, Nara 632, Japan

[6] Family Hosp Satsuma, Dept Psychosomat Med, Kagoshima, Japan

[7] Kyushu Univ, Grad Sch Med Sci, Dept Psychosomat Med, Fukuoka 812, Japan

[8] Univ Occupat & Environm Hlth, Dept Neurol, Div Psychosomat Med, Kitakyushu, Fukuoka 807, Japan

[9] Saitama Social Insurance Hosp, Dept Psychosomat Med, Saitama, Japan

[10] Takei Med Clin, Kagoshima, Japan

[11] Aichi Med Univ Hosp, Div Gen Med, Nagakute, Aichi, Japan

[12] Osaka City Univ, Grad Sch Med, Dept Neuropsychiat, Abeno Ku, Osaka 558, Japan

[13] Hiroshima Univ, Hlth Serv Ctr, Hiroshima, Japan

[14] Yufuin Koseinenkin Hosp, Dept Internal Med, Oita, Japan

[15] Kamibayashi Mem Hosp, Dept Psychosomat Med, Ichinomiya, Aichi, Japan

[16] Int Univ Kagoshima, Grad Sch Welf Soc, Kagoshima, Japan

[17] Azumi Gen Hosp, Dept Psychiat Ikedamachi, Nagano, Japan

[18] Tokyo Kasei Univ, Dept Nutr, Sch Home Econ & Sci, Itabashi Ku, Tokyo, Japan

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2012年 / 159B卷 / 01期

关键词：

eating disorders; body mass index; harm avoidance; lifetime diagnosis; case-control study; EATING-DISORDERS; EUROPEAN POPULATIONS; PERSONALITY-TRAITS; BDNF; METAANALYSIS; TEMPERAMENT; CHARACTER;

D O I：

10.1002/ajmg.b.32000

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Met66 allele of the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene has been reported to be associated with anorexia nervosa (AN), and also lower minimum body mass index (BMI) and higher harm avoidance in AN. We genotyped the Val66Met polymorphism (rs6265) in 689 AN cases and 573 control subjects. There were no significant differences in the genotype or allele frequencies of the Val66Met between AN and control subjects (allele wise, odds ratio=0.920, 95% CI 0.7851.079, P=0.305). No difference was found in minimum BMIs related to Val66Met in AN (one-way ANOVA, P>0.05). Harm avoidance scores on the Temperament and Character Inventory were lower in the Met66 allele carriers (P=0.0074) contrary to the previous report. Thus we were unable to replicate the previous findings that the Met66 allele of the BDNF is associated with AN and that the minimum BMI is lower or the harm avoidance score is higher in AN patients with the Met66 allele. (C) 2011 Wiley Periodicals, Inc.

引用

页码：48 / 52

页数：5

共 18 条

[1]

ARIAS B, 2011, ACTA PSYCHIAT SCAND, DOI DOI 10.1177/0269881111415736

[2] A PSYCHOBIOLOGICAL MODEL OF TEMPERAMENT AND CHARACTER [J].

CLONINGER, CR ;

SVRAKIC, DM ;

PRZYBECK, TR .

ARCHIVES OF GENERAL PSYCHIATRY, 1993, 50 (12) :975-990

[3] Temperament and character profile of eating disorders: A controlled study with the temperament and character inventory [J].

Fassino, S ;

Abbate-Daga, G ;

Amianto, F ;

Leombruni, P ;

Boggio, S ;

Rovera, GG .

INTERNATIONAL JOURNAL OF EATING DISORDERS, 2002, 32 (04) :412-425

[4] Meta-Analysis of the Brain-Derived Neurotrophic Factor Gene (BDNF) Val66Met Polymorphism in Anxiety Disorders and Anxiety-Related Personality Traits [J].

Frustaci, Alessandra ;

Pozzi, Gino ;

Gianfagna, Francesco ;

Manzoli, Lamberto ;

Boccia, Stefania .

NEUROPSYCHOBIOLOGY, 2008, 58 (3-4) :163-170

[5] Brain-derived neurotrophic factor Val66Met and psychiatric disorders:: Meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia [J].

Gratacos, Monica ;

Gonzalez, Juan R. ;

Mercader, Josep M. ;

de Cid, Rafael ;

Urretavizcaya, Mikel ;

Estivill, Xavier .

BIOLOGICAL PSYCHIATRY, 2007, 61 (07) :911-922

[6] Neurotrophins: Roles in neuronal development and function [J].

Huang, EJ ;

Reichardt, LF .

ANNUAL REVIEW OF NEUROSCIENCE, 2001, 24 :677-736

[7] Interaction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traits [J].

Huennerkopf, Regina ;

Strobel, Alexander ;

Gutknecht, Lise ;

Brocke, Burkhard ;

Lesch, Klaus Peter .

NEUROPSYCHOPHARMACOLOGY, 2007, 32 (12) :2552-2560

[8]

KIJIMA N, 1996, SEISHINKA SHINDANGAK, V7, P379

[9] Interaction between Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Recent Negative Stressor in Harm Avoidance [J].

Kim, Seog Ju ;

Cho, Seong-Jin ;

Jang, Ha Min ;

Shin, Jonghan ;

Park, Pil-Whan ;

Lee, Yu Jin ;

Cho, In Hee ;

Choi, Jung-Eun ;

Lee, Heon-Jeong .

NEUROPSYCHOBIOLOGY, 2010, 61 (01) :19-26

[10] Association between the brain-derived neurotrophic factor 196G/A polymorphism and eating disorders [J].

Koizumi, H ;

Hashimoto, K ;

Itoh, K ;

Nakazato, M ;

Shimizu, E ;

Ohgake, S ;

Koike, K ;

Okamura, N ;

Matsushita, S ;

Suzuki, K ;

Murayama, M ;

Higuchi, S ;

Iyol, M .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2004, 127B (01) :125-127

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