The prospective association between periodontal disease and brain imaging outcomes: The Atherosclerosis Risk in Communities study

被引：7

作者：

Adam, Hamdi S. ^{[1
]}

Lakshminarayan, Kamakshi ^{[1
]}

Wang, Wendy ^{[1
]}

Norby, Faye L. ^{[2
]}

Mosley, Thomas ^{[3
]}

Walker, Keenan A. ^{[4
]}

Gottesman, Rebecca F. ^{[5
]}

Meyer, Katie ^{[6
]}

Hughes, Timothy M. ^{[7
]}

Pankow, James S. ^{[1
]}

Wong, Dean F. ^{[8
]}

Jack, Clifford R., Jr. ^{[9
]}

Sen, Souvik ^{[10
]}

Lutsey, Pamela L. ^{[1
]}

Beck, Jim ^{[11
]}

Demmer, Ryan T. ^{[1
,12
]}

机构：

[1] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, 1300 South 2nd St,Suite 300, Minneapolis, MN 55454 USA

[2] Cedars Sinai Hlth Syst, Smidt Heart Inst, Dept Cardiol, Los Angeles, CA USA

[3] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA

[4] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[5] NINDS, Stroke Branch, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA

[6] Univ N Carolina, Dept Nutr, Chapel Hill, NC 27515 USA

[7] Wake Forest Sch Med, Dept Internal Med, Winston Salem, NC 27101 USA

[8] Washington Univ St Louis Missouri, Mallinckrodt Inst Radiol, St Louis, MO USA

[9] Mayo Clin, Dept Radiol, Rochester, MN USA

[10] Univ South Carolina, Sch Med, Dept Neurol, Columbia, SC 29208 USA

[11] Univ N Carolina, Adams Sch Dent, Div Comprehens Oral Hlth Periodontol, Chapel Hill, NC 27515 USA

[12] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA

来源：

JOURNAL OF CLINICAL PERIODONTOLOGY | 2022年 / 49卷 / 04期

基金：

美国国家卫生研究院;

关键词：

cohort studies; dementia; magnetic resonance imaging; periodontal diseases; positron-emission tomography; CORONARY-HEART-DISEASE; CEREBROVASCULAR-DISEASE; COGNITIVE FUNCTION; ORAL-HEALTH; TOOTH LOSS; STROKE; DEMENTIA; ATTRITION; KOREANS;

D O I：

10.1111/jcpe.13586

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Aim We investigate if periodontal disease is prospectively associated with cerebrovascular and neurodegenerative markers of dementia and Alzheimer's pathology. Materials and Methods N = 1306 participants (Visit 5 mean age = 76.5 [standard deviation = 5.4] years) in the Atherosclerosis Risk in Communities study with completed dental exams at Visit 4 underwent brain magnetic resonance imaging scans at Visit 5 while N = 248 underwent positron emission tomography scans. Participants were classified as edentulous or, among the dentate, by the modified Periodontal Profile Class. Brain volumes were regressed on periodontal status in linear regressions. Cerebrovascular measures and beta-amyloid positivity were regressed on periodontal status in logistic regressions. Results Periodontal disease was not associated with brain volumes, microhaemorrhages, or elevated beta-amyloid. Compared with periodontally healthy individuals, odds ratios [95% confidence interval] for all-type infarcts were 0.37 [0.20, 0.65] for severe tooth loss and 0.56 [0.31, 0.99] for edentulous participants. Conclusions Within the limitations of this study, periodontal disease was not associated with altered brain volumes, microhaemorrhages, or beta-amyloid positivity. Tooth loss was associated with lower odds of cerebral infarcts.

引用

页码：322 / 334

页数：13

共 44 条

[1] Periodontal profile class is associated with prevalent diabetes, coronary heart disease, stroke, and systemic markers of C-reactive protein and interleukin-6 [J].