How do I begin? Sensing extracellular stress to maintain yeast cell wall integrity

被引：77

作者：

Jendretzki, Arne ^{[1
]}

Wittland, Janina ^{[1
]}

Wilk, Sabrina ^{[1
]}

Straede, Andrea ^{[1
]}

Heinisch, Juergen J. ^{[1
]}

机构：

[1] Univ Osnabruck, Fac Biol & Chem, Dept Genet, D-49076 Osnabruck, Germany

来源：

EUROPEAN JOURNAL OF CELL BIOLOGY | 2011年 / 90卷 / 09期

关键词：

Saccharomyces cerevisiae; Wsc1; Wsc2; Mid2; MAP kinase cascade; Mechanosensor; PROTEIN-KINASE-C; SACCHAROMYCES-CEREVISIAE; SIGNALING PATHWAYS; SURFACE SENSORS; WSC1; GENE; MID2; FAMILY; IDENTIFICATION; EXPRESSION;

D O I：

10.1016/j.ejcb.2011.04.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cell wall integrity (CWI) signalling pathway is necessary to remodel the yeast cell wall during normal morphogenesis and in response to cell surface stress. In the Baker's yeast Saccharomyces cerevisiae, a set of five membrane-spanning sensors, namely Wsc1, Wsc2, Wsc3, Mid2 and Mtl1, detect perturbations in the cell wall and/or the plasma membrane and activate a downstream signal transduction pathway with a central MAP kinase module. As a consequence, the expression of genes whose products are involved in cell wall structure and remodelling is induced. This review summarises our recent results on sensor structure and function, as well as the advances made regarding sensor mechanics. (C) 2011 Elsevier GmbH. All rights reserved.

引用

页码：740 / 744

页数：5

共 41 条

[11] Single-Molecule Atomic Force Microscopy Reveals Clustering of the Yeast Plasma-Membrane Sensor Wsc1 [J].

Heinisch, Juergen J. ;

Dupres, Vincent ;

Wilk, Sabrina ;

Jendretzki, Arne ;

Dufrene, Yves F. .

PLOS ONE, 2010, 5 (06)

[12] Measurement of the mechanical behavior of yeast membrane sensors using single-molecule atomic force microscopy [J].

Heinisch, Juergen J. ;

Dupres, Vincent ;

Alsteens, David ;

Dufrene, Yves F. .

NATURE PROTOCOLS, 2010, 5 (04) :670-677

[13] Protein N-glycosylation determines functionality of the Saccharomyces cerevisiae cell wall integrity sensor Mid2p [J].

Hutzler, Franziska ;

Gerstl, Ronald ;

Lommel, Mark ;

Strahl, Sabine .

MOLECULAR MICROBIOLOGY, 2008, 68 (06) :1438-1449

[14] MKK1 AND MKK2, WHICH ENCODE SACCHAROMYCES-CEREVISIAE MITOGEN-ACTIVATED PROTEIN KINASE-KINASE HOMOLOGS, FUNCTION IN THE PATHWAY MEDIATED BY PROTEIN-KINASE-C [J].

IRIE, K ;

TAKASE, M ;

LEE, KS ;

LEVIN, DE ;

ARAKI, H ;

MATSUMOTO, K ;

OSHIMA, Y .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (05) :3076-3083

[15] Saccharomyces cerevisiae Mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway [J].

Ketela, T ;

Green, R ;

Bussey, H .

JOURNAL OF BACTERIOLOGY, 1999, 181 (11) :3330-3340

[16] Pathological roles of MAPK signaling pathways in human diseases [J].

Kim, Eun Kyung ;

Choi, Eui-Ju .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2010, 1802 (04) :396-405

[17] Cell wall construction in Saccharomyces cerevisiae [J].

Klis, FM ;

Boorsma, A ;

De Groot, PWJ .

YEAST, 2006, 23 (03) :185-202

[18] A YEAST MITOGEN-ACTIVATED PROTEIN-KINASE HOMOLOG (MPK1P) MEDIATES SIGNALING BY PROTEIN-KINASE-C [J].

LEE, KS ;

IRIE, K ;

GOTOH, Y ;

WATANABE, Y ;

ARAKI, H ;

NISHIDA, E ;

MATSUMOTO, K ;

LEVIN, DE .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (05) :3067-3075

[19] DOMINANT MUTATIONS IN A GENE ENCODING A PUTATIVE PROTEIN-KINASE (BCK1) BYPASS THE REQUIREMENT FOR A SACCHAROMYCES-CEREVISIAE PROTEIN-KINASE-C HOMOLOG [J].

LEE, KS ;

LEVIN, DE .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (01) :172-182

[20] A CANDIDATE PROTEIN KINASE-C GENE, PKC1, IS REQUIRED FOR THE SACCHAROMYCES-CEREVISIAE CELL-CYCLE [J].

LEVIN, DE ;

FIELDS, FO ;

KUNISAWA, R ;

BISHOP, JM ;

THORNER, J .

CELL, 1990, 62 (02) :213-224

← 1 2 3 4 5 →