How do I begin? Sensing extracellular stress to maintain yeast cell wall integrity

被引：74
作者：
Jendretzki, Arne [1 ]
Wittland, Janina [1 ]
Wilk, Sabrina [1 ]
Straede, Andrea [1 ]
Heinisch, Juergen J. [1 ]
机构：
[1] Univ Osnabruck, Fac Biol & Chem, Dept Genet, D-49076 Osnabruck, Germany
来源：
EUROPEAN JOURNAL OF CELL BIOLOGY | 2011年 / 90卷 / 09期
关键词：
Saccharomyces cerevisiae; Wsc1; Wsc2; Mid2; MAP kinase cascade; Mechanosensor; PROTEIN-KINASE-C; SACCHAROMYCES-CEREVISIAE; SIGNALING PATHWAYS; SURFACE SENSORS; WSC1; GENE; MID2; FAMILY; IDENTIFICATION; EXPRESSION;
D O I：
10.1016/j.ejcb.2011.04.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The cell wall integrity (CWI) signalling pathway is necessary to remodel the yeast cell wall during normal morphogenesis and in response to cell surface stress. In the Baker's yeast Saccharomyces cerevisiae, a set of five membrane-spanning sensors, namely Wsc1, Wsc2, Wsc3, Mid2 and Mtl1, detect perturbations in the cell wall and/or the plasma membrane and activate a downstream signal transduction pathway with a central MAP kinase module. As a consequence, the expression of genes whose products are involved in cell wall structure and remodelling is induced. This review summarises our recent results on sensor structure and function, as well as the advances made regarding sensor mechanics. (C) 2011 Elsevier GmbH. All rights reserved.
引用
收藏
页码：740 / 744
页数：5
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