How do I begin? Sensing extracellular stress to maintain yeast cell wall integrity

被引：77

作者：

Jendretzki, Arne ^{[1
]}

Wittland, Janina ^{[1
]}

Wilk, Sabrina ^{[1
]}

Straede, Andrea ^{[1
]}

Heinisch, Juergen J. ^{[1
]}

机构：

[1] Univ Osnabruck, Fac Biol & Chem, Dept Genet, D-49076 Osnabruck, Germany

来源：

EUROPEAN JOURNAL OF CELL BIOLOGY | 2011年 / 90卷 / 09期

关键词：

Saccharomyces cerevisiae; Wsc1; Wsc2; Mid2; MAP kinase cascade; Mechanosensor; PROTEIN-KINASE-C; SACCHAROMYCES-CEREVISIAE; SIGNALING PATHWAYS; SURFACE SENSORS; WSC1; GENE; MID2; FAMILY; IDENTIFICATION; EXPRESSION;

D O I：

10.1016/j.ejcb.2011.04.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cell wall integrity (CWI) signalling pathway is necessary to remodel the yeast cell wall during normal morphogenesis and in response to cell surface stress. In the Baker's yeast Saccharomyces cerevisiae, a set of five membrane-spanning sensors, namely Wsc1, Wsc2, Wsc3, Mid2 and Mtl1, detect perturbations in the cell wall and/or the plasma membrane and activate a downstream signal transduction pathway with a central MAP kinase module. As a consequence, the expression of genes whose products are involved in cell wall structure and remodelling is induced. This review summarises our recent results on sensor structure and function, as well as the advances made regarding sensor mechanics. (C) 2011 Elsevier GmbH. All rights reserved.

引用

页码：740 / 744

页数：5

共 41 条

[1] Milk and sugar: Regulation of cell wall synthesis in the milk yeast Kluyveromyces lactis [J].

Backhaus, Katja ;

Buchwald, Ulf ;

Heppeler, Nele ;

Schmitz, Hans-Peter ;

Rodicio, Rosaura ;

Heinisch, Juergen J. .

EUROPEAN JOURNAL OF CELL BIOLOGY, 2011, 90 (09) :745-750

[2] Characterization of Sensor-Specific Stress Response by Transcriptional Profiling of wsc1 and mid2 Deletion Strains and Chimeric Sensors in Saccharomyces cerevisiae [J].

Bermejo, Clara ;

Garcia, Raul ;

Straede, Andrea ;

Rodriguez-Pena, Jose M. ;

Nombela, Cesar ;

Heinisch, Juergen J. ;

Arroyo, Javier .

OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 2010, 14 (06) :679-688

[3] Molecular characterization of a novel β-1,3-exoglucanase related to mycoparasitism of Trichoderma harzianum [J].

Cohen-Kupiec, R ;

Broglie, KE ;

Friesem, D ;

Broglie, RM ;

Chet, I .

GENE, 1999, 226 (02) :147-154

[4] Cell wall stress depolarizes cell growth via hyperactivation of RHO1 [J].

Delley, PA ;

Hall, MN .

JOURNAL OF CELL BIOLOGY, 1999, 147 (01) :163-174

[5] Measuring Cell Wall Thickness in Living Yeast Cells Using Single Molecular Rulers [J].

Dupres, Vincent ;

Dufrene, Yves F. ;

Heinisch, Juergen J. .

ACS NANO, 2010, 4 (09) :5498-5504

[6] The yeast Wsc1 cell surface sensor behaves like a nanospring in vivo [J].

Dupres, Vincent ;

Alsteens, David ;

Wilk, Sabrina ;

Hansen, Benjamin ;

Heinisch, Juergen J. ;

Dufrene, Yves F. .

NATURE CHEMICAL BIOLOGY, 2009, 5 (11) :857-862

[7] A role for the Pkc1 MAP kinase pathway of Saccharomyces cerevisiae in bud emergence and identification of a putative upstream regulator [J].

Gray, JV ;

Ogas, JP ;

Kamada, Y ;

Stone, M ;

Levin, DE ;

Herskowitz, I .

EMBO JOURNAL, 1997, 16 (16) :4924-4937

[8] A synthetic analysis of the Saccharomyces cerevisiae stress sensor Mid2p, and identification of a Mid2p-interacting protein, Zeo1p, that modulates the PKC1-MPK1 cell integrity pathway [J].

Green, R ;

Lesage, G ;

Sdicu, AM ;

Ménard, P ;

Bussey, H .

MICROBIOLOGY-SGM, 2003, 149 :2487-2499

[9] Baker's yeast as a tool for the development of antifungal kinase inhibitors - targeting protein kinase C and the cell integrity pathway [J].

Heinisch, JJ .

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2005, 1754 (1-2) :171-182

[10] Is there anyone out there?-Single-molecule atomic force microscopy meets yeast genetics to study sensor functions [J].

Heinisch, Juergen J. ;

Dufrene, Yves F. .

INTEGRATIVE BIOLOGY, 2010, 2 (09) :408-415

← 1 2 3 4 5 →