Decoupling of structural and functional brain connectivity in older adults with white matter hyperintensities

被引：62

作者：

Reijmer, Y. D. ^{[1
]}

Schultz, A. P. ^{[2
,4
]}

Leemans, A. ^{[5
]}

O'Sullivan, M. J. ^{[6
]}

Gurol, M. E. ^{[1
]}

Sperling, R. ^{[1
,2
,4
,7
]}

Greenberg, S. M. ^{[1
]}

Viswanathan, A. ^{[1
]}

Hedden, T. ^{[3
,4
]}

机构：

[1] Harvard Univ, Sch Med, Dept Neurol, Massachusetts Gen Hosp, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Psychiat, Massachusetts Gen Hosp, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Radiol, Massachusetts Gen Hosp, Boston, MA 02115 USA

[4] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA

[5] Univ Med Ctr Utrecht, Image Sci Inst, Utrecht, Netherlands

[6] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Basic & Clin Neurosci, London WC2R 2LS, England

[7] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Neurol, Boston, MA 02115 USA

来源：

NEUROIMAGE | 2015年 / 117卷

基金：

美国国家卫生研究院;

关键词：

Functional MRI; Diffusion tensor imaging; Connectivity; Cognition; Aging; White matter hyperintensities; DEFAULT-MODE; DIFFUSION MRI; MICROSTRUCTURAL INTEGRITY; STATE; AGE; CINGULUM; NETWORK; MOTION; DAMAGE; DEACTIVATIONS;

D O I：

10.1016/j.neuroimage.2015.05.054

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Age-related impairments in the default network (DN) have been related to disruptions in connecting white matter tracts. We hypothesized that the local correlation between DN structural and functional connectivity is negatively affected in the presence of global white matter injury. In 125 clinically normal older adults, we tested whether the relationship between structural connectivity (via diffusion imaging tractography) and functional connectivity (via resting-state functional MRI) of the posterior cingulate cortex (PCC) and medial prefrontal frontal cortex (MPFC) of the DN was altered in the presence of white matter hyperintensities (WMH). A significant correlation was observed between microstructural properties of the cingulum bundle and MPFC-PCC functional connectivity in individuals with low WMH load, but not with high WMH load. No correlation was observed between PCC-MPFC functional connectivity and microstructure of the inferior longitudinal fasciculus, a tract not passing through the PCC or MPFC. Decoupling of connectivity, measured as the absolute difference between structural and functional connectivity, in the high WMH group was related to poorer executive functioning and memory performance. These results suggest that such decoupling may reflect reorganization of functional networks in response to global white matter pathology and may provide an early marker of clinically relevant network alterations. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：222 / 229

页数：8

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