Chronic hepatitis B: immune pathogenesis and emerging immunotherapeutics

被引：16

作者：

Chang, Kyong-Mi ^{[1
,2
]}

Liu, Mengfei ^{[1
]}

机构：

[1] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Philadelphia Corporal Michael J Crescenz VA Med C, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2016年 / 30卷

关键词：

REGULATORY T-CELLS; CHIMERIC ANTIGEN RECEPTOR; SENSOR RIG-I; VIRAL CLEARANCE; VIRUS INFECTION; PEGINTERFERON ALPHA-2A; METABOLIC-REGULATION; LAMIVUDINE TREATMENT; COMBINATION THERAPY; PROGRAMMED DEATH-1;

D O I：

10.1016/j.coph.2016.07.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hepatitis B virus (HBV) evades, subverts, activates and regulates host immune components, thereby impacting its natural history and disease pathogenesis. Recent advances in our understanding of immune interactions in chronic viral infection and tumor therapy are applicable to chronic hepatitis B (CHB). With recent successes of tumor immunotherapy, there is a renewed interest in exploring immunotherapeutics in achieving sustained and functional cure of chronic hepatitis B. In this review, we discuss aspects of host innate and adaptive immune regulatory and pathogenic responses relevant for HBV infection. We also highlight several immune modulatory approaches in clinical development to treat CHB.

引用

页码：93 / 105

页数：13

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