Copper-catalyzed reductive coupling of tosylhydrazones with amines: A convenient route to α-branched amines

被引：83
作者：
Hamze, Abdallah [1 ]
Treguier, Bret [1 ]
Brion, Jean-Daniel [1 ]
Alami, Mouad [1 ]
机构：
[1] Univ Paris 11, CNRS, Chim Therapeut Lab, Fac Pharm,BioCIS UMR 8076, F-92296 Chatenay Malabry, France
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 18期
关键词：
STRAIGHTFORWARD 3-COMPONENT SYNTHESIS; AROMATIC ORGANOZINC REAGENTS; ARYL HALIDES SYNTHESIS; N-TOSYLHYDRAZONES; ORGANIC-SYNTHESIS; DIAZO-COMPOUNDS; DIARYLMETHYLAMINES; ALKYLATION; ALDEHYDES; OLEFINS;
D O I：
10.1039/c1ob05664f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general procedure for the reductive coupling of N-tosylhydrazones with amines in the presence of Cu(acac)(2) and Cs2CO3 has been developed. The protocol is very effective and chemoselective with various primary and secondary aliphatic amines, aminoalcohols as well as azole derivatives to give alpha-branched amines in good yields.
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收藏
页码：6200 / 6204
页数：5
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