D-dimer: Preanalytical, analytical, postanalytical variables, and clinical applications

被引：182

作者：

Favresse, Julien ^{[1
]}

Lippi, Giuseppe ^{[2
]}

Roy, Pierre-Marie ^{[3
]}

Chatelain, Bernard ^{[1
]}

Jacqmin, Hugues ^{[1
]}

ten Cate, Hugo ^{[4
]}

Mullier, Francois ^{[1
]}

机构：

[1] Catholic Univ Louvain, CHU UCL Namur, Namur Thrombosis & Hemostasis Ctr, Hematol Lab, Yvoir, Belgium

[2] Univ Hosp Verona, Sect Clin Biochem, Verona, Italy

[3] Univ Angers, CHU Angers, Inst MITOVASC, Dept Med Urgence, Angers, France

[4] Maastricht Univ, Med Ctr, Cardiovasc Inst, Dept Internal Med, Maastricht, Netherlands

来源：

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES | 2018年 / 55卷 / 08期

关键词：

D-dimer; preanalytical; analytical; postanalytical; venous thromboembolism; DEEP-VEIN THROMBOSIS; QUANTITATIVE D-DIMER; SUSPECTED VENOUS THROMBOEMBOLISM; PARTIAL THROMBOPLASTIN TIME; ELEVATED D-DIMER; EXCLUDING PULMONARY-EMBOLISM; ACUTE AORTIC DISSECTION; DETECTION RISK SCORE; DIRECT MEDICAL COSTS; DIAGNOSTIC WORK-UP;

D O I：

10.1080/10408363.2018.1529734

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

D-dimer is a soluble fibrin degradation product deriving from the plasmin-mediated degradation of cross-linked fibrin. D-dimer can hence be considered a biomarker of activation of coagulation and fibrinolysis, and it is routinely used for ruling out venous thromboembolism (VTE). D-dimer is increasingly used to assess the risk of VTE recurrence and to help define the optimal duration of anticoagulation treatment in patients with VTE, for diagnosing disseminated intravascular coagulation, and for screening medical patients at increased risk of VTE. This review is aimed at (1) revising the definition of D-dimer; (2) discussing preanalytical variables affecting the measurement of D-dimer; (3) reviewing and comparing assay performance and some postanalytical variables (e.g. different units and age-adjusted cutoffs); and (4) discussing the use of D-dimer measurement across different clinical settings.

引用

页码：548 / 577

页数：30

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