Catalytic Asymmetric Synthesis of Spirooxindoles by a Mannich-Type Reaction of Isothiocyanato Oxindoles

被引：114

作者：

Kato, Shota ^{[1
]}

Yoshino, Tatsuhiko ^{[1
]}

Shibasaki, Masakatsu ^{[2
]}

Kanai, Motomu ^{[1
,3
]}

Matsunaga, Shigeki ^{[1
,3
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

[2] Inst Microbial Chem, Shinagawa Ku, Tokyo 1410021, Japan

[3] ERATO Japan Sci & Technol Agcy, Kanai Life Sci Catalysis Project, Tokyo 1130033, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 28期

关键词：

asymmetric catalysis; asymmetric synthesis; Mannich reaction; oxindoles; salen; SCHIFF-BASE CATALYSIS; ENANTIOSELECTIVE SYNTHESIS; MULTIPLE STEREOCENTERS; SPIROCYCLIC OXINDOLES; NATURAL-PRODUCTS; 3+2 ANNULATION; DIELS-ALDER; CONSTRUCTION; ANTAGONISTS; P53;

D O I：

10.1002/anie.201203005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Easy access: A strontium/Schiff base complex as catalyst for the title reaction provided straightforward access to enantiomerically enriched spiro[imidazolidine-4,3'-oxindole] compounds, as well as a spiro[imidazoline-4, 3'-oxindole] through a two-step conversion from the Mannich adduct. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：7007 / 7010

页数：4

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