The role of cellular objectives and selective pressures in metabolic pathway evolution

被引:23
作者
Nam, Hojung [1 ]
Conrad, Tom M. [2 ]
Lewis, Nathan E. [1 ]
机构
[1] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA
基金
美国国家卫生研究院;
关键词
COLI K-12 MG1655; ESCHERICHIA-COLI; ADAPTIVE EVOLUTION; LABORATORY EVOLUTION; ETHANOL TOLERANCE; OPTIMAL-GROWTH; NETWORKS; RECONSTRUCTION; CONSISTENT; REVEALS;
D O I
10.1016/j.copbio.2011.03.006
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Evolution results from molecular-level changes in an organism, thereby producing novel phenotypes and, eventually novel species. However, changes in a single gene can lead to significant changes in biomolecular networks through the gain and loss of many molecular interactions. Thus, significant insights into microbial evolution have been gained through the analysis and comparison of reconstructed metabolic networks. However, challenges remain from reconstruction incompleteness and the inability to experiment with evolution on the timescale necessary for new species to arise. Despite these challenges, experimental laboratory evolution of microbes has provided some insights into the cellular objectives underlying evolution, under the constraints of nutrient availability and the use of mechanisms that protect cells from extreme conditions.
引用
收藏
页码:595 / 600
页数:6
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