Membranous nephropathy associated with immunoglobulin G4-related disease successfully treated with obinutuzumab

被引：22
作者：
Ginthoer, Noemi E. [1 ]
Artinger, Katharina [1 ]
Pollheimer, Marion J. [2 ]
Stradner, Martin H. [3 ]
Eller, Kathrin [1 ]
机构：
[1] Med Univ Graz, Div Nephrol, Graz, Austria
[2] Med Univ Graz, Inst Pathol, Graz, Austria
[3] Med Univ Graz, Div Rheumatol & Immunol, Graz, Austria
来源：
CLINICAL KIDNEY JOURNAL | 2022年 / 15卷 / 03期
关键词：
B lymphocytes; IgG4-related disease; kidney disease; membranous nephropathy;
D O I：
10.1093/ckj/sfab250
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Immunoglobulin G4 (IgG4)-releated disease is typically associated with interstitial nephritis, but rare cases of idiopathic membranous nephropathy as a renal manifestation have been described. Obinutuzumab was successfully used in refractory membranous nephropathy, but evidence for the treatment of IgG4-related disease with obinutuzumab is lacking. We report one patient's case with membranous nephropathy associated with IgG4-related disease who was treated with obinutuzumab following an anaphylactic reaction to rituximab. Obinutuzumab treatment resulted in a sustained complete remission of membranous nephropathy and a decrease of IgG4 to the normal range. This case demonstrates that membranous nephropathy associated with IgG4-related disease can be treated successfully with obinutuzumab.
引用
收藏
页码：564 / 566
页数：3
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