Membranous nephropathy associated with immunoglobulin G4-related disease successfully treated with obinutuzumab

被引：19

作者：

Ginthoer, Noemi E. ^{[1
]}

Artinger, Katharina ^{[1
]}

Pollheimer, Marion J. ^{[2
]}

Stradner, Martin H. ^{[3
]}

Eller, Kathrin ^{[1
]}

机构：

[1] Med Univ Graz, Div Nephrol, Graz, Austria

[2] Med Univ Graz, Inst Pathol, Graz, Austria

[3] Med Univ Graz, Div Rheumatol & Immunol, Graz, Austria

来源：

CLINICAL KIDNEY JOURNAL | 2022年 / 15卷 / 03期

关键词：

B lymphocytes; IgG4-related disease; kidney disease; membranous nephropathy;

D O I：

10.1093/ckj/sfab250

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Immunoglobulin G4 (IgG4)-releated disease is typically associated with interstitial nephritis, but rare cases of idiopathic membranous nephropathy as a renal manifestation have been described. Obinutuzumab was successfully used in refractory membranous nephropathy, but evidence for the treatment of IgG4-related disease with obinutuzumab is lacking. We report one patient's case with membranous nephropathy associated with IgG4-related disease who was treated with obinutuzumab following an anaphylactic reaction to rituximab. Obinutuzumab treatment resulted in a sustained complete remission of membranous nephropathy and a decrease of IgG4 to the normal range. This case demonstrates that membranous nephropathy associated with IgG4-related disease can be treated successfully with obinutuzumab.

引用

页码：564 / 566

页数：3

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