Remote control of signaling pathways using magnetic nanoparticles

被引：22

作者：

Bonnemay, Louise ^{[1
]}

Hoffmann, Celine ^{[1
]}

Gueroui, Zoher ^{[1
]}

机构：

[1] PSL Res Univ, UPMC, CNRS, UMR 8640,ENS,Dept Chim, Paris, France

来源：

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY | 2015年 / 7卷 / 03期

关键词：

IN-VITRO; SPATIOTEMPORAL CONTROL; CELL BIOLOGY; ION CHANNELS; ACTIVATION; FIELD; SYSTEMS; GROWTH; GRADIENTS; PROTEINS;

D O I：

10.1002/wnan.1313

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Our ability to quantitatively control the spatiotemporal properties of cellular information processing is key for understanding biological systems at both mechanistic and systemic level. In this context, magnetic field offers a relevant strategy of control over cellular processes that broaden the toolbox currently available in cell biology. Among the increasing number of methods, we will focus on recent advances based on magnetic nanoparticles conjugated to proteins to trigger specific signaling pathways and cellular processes. Extracellular or intracellular manipulations of nanoparticles permit magnetic control of ion channels and membrane receptor activation, protein positioning within cells and cytoskeleton spatial engineering. These approaches provide powerful strategies to examine the organization principles of living cells. (C) 2014Wiley Periodicals, Inc.

引用

页码：342 / 354

页数：13

共 66 条

[1] The Decapentaplegic morphogen gradient: from pattern formation to growth regulation [J].

Affolter, Markus ;

Basler, Konrad .

NATURE REVIEWS GENETICS, 2007, 8 (09) :663-674

[2] Regulation of Microtubule Dynamics by Reaction Cascades Around Chromosomes [J].

Athale, Chaitanya A. ;

Dinarina, Ana ;

Mora-Coral, Maria ;

Pugieux, Celine ;

Nedelec, Francois ;

Karsenti, Eric .

SCIENCE, 2008, 322 (5905) :1243-1247

[3] Ultra Magnetic Liposomes for MR Imaging, Targeting, and Hyperthermia [J].

Bealle, Gaelle ;

Di Corato, Riccardo ;

Kolosnjaj-Tabi, Jelena ;

Dupuis, Vincent ;

Clement, Olivier ;

Gazeau, Florence ;

Wilhelm, Claire ;

Menager, Christine .

LANGMUIR, 2012, 28 (32) :11843-11851

[4]

Bhargava A., 2018, Panchjanya, P8

[5] Engineering Spatial Gradients of Signaling Proteins Using Magnetic Nanoparticles [J].

Bonnemay, L. ;

Hostachy, S. ;

Hoffmann, C. ;

Gautier, J. ;

Gueroui, Z. .

NANO LETTERS, 2013, 13 (11) :5147-5152

[6] Optogenetic protein clustering and signaling activation in mammalian cells [J].

Bugaj, Lukasz J. ;

Choksi, Atri T. ;

Mesuda, Colin K. ;

Kane, Ravi S. ;

Schaffer, David V. .

NATURE METHODS, 2013, 10 (03) :249-252

[7] Scaling properties of cell and organelle size [J].

Chan, Yee-Hung M. ;

Marshall, Wallace F. .

ORGANOGENESIS, 2010, 6 (02) :88-96

[8] Systems- and Molecular-Level Elucidation of Signaling Processes Through Chemistry [J].

Chiang, Kyle P. ;

Muir, Tom W. .

SCIENCE SIGNALING, 2008, 1 (42) :pe45

[9] Working Together: The Combined Application of a Magnetic Field and Penetratin for the Delivery of Magnetic Nanoparticles to Cells in 3D [J].

Child, Hannah W. ;

del Pino, Pablo A. ;

De la Fuente, Jesus M. ;

Hursthouse, Andrew S. ;

Stirling, David ;

Mullen, Margaret ;

McPhee, Gordon M. ;

Nixon, Colin ;

Jayawarna, Vineetha ;

Berry, Catherine C. .

ACS NANO, 2011, 5 (10) :7910-7919

[10]

Cho MH, 2012, NAT MATER, V11, P1038, DOI [10.1038/NMAT3430, 10.1038/nmat3430]

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