Microglia, Lifestyle Stress, and Neurodegeneration

被引：237
作者：
Madore, Charlotte [1 ]
Yin, Zhuoran [1 ]
Leibowitz, Jeffrey [1 ]
Butovsky, Oleg [1 ,2 ]
机构：
[1] Harvard Med Sch, Ann Romney Ctr Neurol Dis, Dept Neurol, Brigham & Womens Hosp, Boston, MA 02115 USA
[2] Harvard Med Sch, Evergrande Ctr Immunol Dis, Brigham & Womens Hosp, Boston, MA 02115 USA
来源：
IMMUNITY | 2020年 / 52卷 / 02期
基金：
英国医学研究理事会;
关键词：
CHAIN FATTY-ACIDS; INTESTINAL BACTERIAL OVERGROWTH; AMYOTROPHIC-LATERAL-SCLEROSIS; LOW-GRADE INFLAMMATION; ALZHEIMERS-DISEASE; GUT-MICROBIOTA; APOLIPOPROTEIN-E; AMYLOID-BETA; MEDITERRANEAN DIET; MULTIPLE-SCLEROSIS;
D O I：
10.1016/j.immuni.2019.12.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent years have witnessed a revolution in our understanding of microglia biology, including their major role in the etiology and pathogenesis of neurodegenerative diseases. Technological advances have enabled the identification of microglial signatures in health and disease, including the development of new models to investigate and manipulate human microglia in vivo in the context of disease. In parallel, genetic association studies have identified several gene risk factors associated with Alzheimer's disease that are specifically or highly expressed by microglia in the central nervous system (CNS). Here, we discuss evidence for the effect of stress, diet, sleep patterns, physical activity, and microbiota composition on microglia biology and consider how lifestyle might influence an individual's predisposition to neurodegenerative diseases. We discuss how different lifestyles and environmental factors might regulate microglia, potentially leading to increased susceptibility to neurodegenerative disease, and we highlight the need to investigate the contribution of modern environmental factors on microglia modulation in neurodegeneration.
引用
收藏
页码：222 / 240
页数：19
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