Steric promotion of the intramolecular Pauson-Khand reaction of aryl enynes

被引：6
|
作者：
Madu, Christian E. [1 ]
Lovely, Carl J. [1 ]
机构：
[1] Univ Texas, Dept Chem & Biochem, Arlington, TX 76019 USA
来源：
SYNLETT | 2007年 / 13期
关键词：
organometallic; substituent effects; cyclization; stereoselectivity; cobalt-alkyne complexes; MEDIUM-SIZED RINGS; CONSTRUCTION; CHEMISTRY; NICHOLAS; CATIONS;
D O I：
10.1055/s-2007-984880
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The intramolecular Pauson-Khand reaction of 1,8-enynes derived from salicylaldehyde derivatives has been investigated. Substrates derived from salicylaldehyde itself reacted poorly in this reaction, but related substrates containing ortho-tert-butyl substituents participated quite effectively and in many cases the cyclizations proceeded with high levels of diastereoselectivity.
引用
收藏
页码：2011 / 2016
页数：6
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