Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands

被引：161
作者：
Giraudo, SQ
Billington, CJ
Levine, AS
机构：
[1] VA Med Ctr, Res Serv 151, Minnesota Obes Ctr, Minneapolis, MN 55417 USA
[2] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Dept Food Sci & Nutr, St Paul, MN 55108 USA
来源：
BRAIN RESEARCH | 1998年 / 809卷 / 02期
关键词：
paraventricular nucleus; MT II; SHU9119; MC4-receptor; food intake;
D O I：
10.1016/S0006-8993(98)00837-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
It has been reported that intraventricular administration of the melanocortin 4 receptor (MCL4-R) agonist MT II and antagonist SHU9119 alter food intake. We found that MT II and SHU9119 have extremely potent effects on feeding when injected in the paraventricular nucleus (PVN), a site where MC4-R gene expression is very high. Our finding provides direct evidence that MC4-R signaling is important is mediating food intake and that melanocortin neurons in the PVN exert a tonic inhibition of feeding behavior. Chronic disruption of this inhibitory signal is a possible explanation of the agouti-obesity syndrome. (C) 1998 Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码：302 / 306
页数：5
相关论文
共 14 条
[1]   HYPOTHALAMIC AND GENETIC OBESITY IN EXPERIMENTAL-ANIMALS - AUTONOMIC AND ENDOCRINE HYPOTHESIS [J].
BRAY, GA ;
YORK, DA .
PHYSIOLOGICAL REVIEWS, 1979, 59 (03) :719-809
[2]  
Cone RD, 1996, RECENT PROG HORM RES, V51, P287
[3]  
CONE RD, 1996, RECENT PROG HORM RES, V51, P318
[4]   Role of melanocortinergic neurons in feeding and the agouti obesity syndrome [J].
Fan, W ;
Boston, BA ;
Kesterson, RA ;
Hruby, VJ ;
Cone, RD .
NATURE, 1997, 385 (6612) :165-168
[5]   Targeted disruption of the melanocortin-4 receptor results in obesity in mice [J].
Huszar, D ;
Lynch, CA ;
FairchildHuntress, V ;
Dunmore, JH ;
Fang, Q ;
Berkemeier, LR ;
Gu, W ;
Kesterson, RA ;
Boston, BA ;
Cone, RD ;
Smith, FJ ;
Campfield, LA ;
Burn, P ;
Lee, F .
CELL, 1997, 88 (01) :131-141
[6]   AGOUTI PROTEIN IS AN ANTAGONIST OF THE MELANOCYTE-STIMULATING-HORMONE RECEPTOR [J].
LU, DS ;
WILLARD, D ;
PATEL, IR ;
KADWELL, S ;
OVERTON, L ;
KOST, T ;
LUTHER, M ;
CHEN, WB ;
WOYCHIK, RP ;
WILKISON, WO ;
CONE, RD .
NATURE, 1994, 371 (6500) :799-802
[7]   Obesity, diabetes and functions for proopiomelanocortin-derived peptides [J].
Mountjoy, KG ;
Wong, J .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1997, 128 (1-2) :171-177
[8]   LOCALIZATION OF THE MELANOCORTIN-4 RECEPTOR (MC4-R) IN NEUROENDOCRINE AND AUTONOMIC CONTROL-CIRCUITS IN THE BRAIN [J].
MOUNTJOY, KG ;
MORTRUD, MT ;
LOW, MJ ;
SIMERLY, RB ;
CONE, RD .
MOLECULAR ENDOCRINOLOGY, 1994, 8 (10) :1298-1308
[9]  
Paxinos G., 1986, RAT BRAIN STEREOTAXI, Vsecond
[10]   ACTH-(1-24) AND ALPHA-MSH ANTAGONIZE FEEDING-BEHAVIOR STIMULATED BY KAPPA OPIATE AGONISTS [J].
POGGIOLI, R ;
VERGONI, AV ;
BERTOLINI, A .
PEPTIDES, 1986, 7 (05) :843-848
12