Chronobiology and Chronotherapy of Osteoporosis

被引：22
作者：
Winter, Elizabeth M. [1 ,2 ,3 ]
Kooijman, Sander [1 ,2 ]
Appelman-Dijkstra, Natasha M. [1 ,2 ,3 ]
Meijer, Onno C. [1 ,2 ]
Rensen, Patrick Cn [1 ,2 ]
Schilperoort, Maaike [1 ,2 ]
机构：
[1] Leiden Univ Med Ctr, Dept Med, Div Endocrinol, Postal Zone C7-Q,POB 9600, NL-2300 RC Leiden, Netherlands
[2] Einthoven Lab Expt Vasc Med, Leiden, Netherlands
[3] Leiden Univ Med Ctr, Ctr Bone Qual, Dept Med, Leiden, Netherlands
来源：
JBMR PLUS | 2021年 / 5卷 / 10期
关键词：
BIOLOGICAL CLOCK; BONE REMODELING; CHRONOTHERAPY; CIRCADIAN RHYTHM; FRACTURES; OSTEOPOROSIS; BONE-MINERAL DENSITY; VERTEBRAL FRACTURE RISK; CIRCADIAN GENE-EXPRESSION; SERUM PARATHYROID-HORMONE; POSTMENOPAUSAL WOMEN; TURNOVER MARKERS; OSTEOBLAST DIFFERENTIATION; PHYSIOLOGICAL-ROLE; BINDING PROTEIN; MESSENGER-RNA;
D O I：
10.1002/jbm4.10504
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Physiological circadian (ie, 24-hour) rhythms are critical for bone health. Animal studies have shown that genes involved in the intrinsic molecular clock demonstrate potent circadian expression patterns in bone and that genetic disruption of these clock genes results in a disturbed bone structure and quality. More importantly, circulating markers of bone remodeling show diurnal variation in mice as well as humans, and circadian disruption by, eg, working night shifts is associated with the bone remodeling disorder osteoporosis. In this review, we provide an overview of the current literature on rhythmic bone remodeling and its underlying mechanisms and identify critical knowledge gaps. In addition, we discuss novel (chrono)therapeutic strategies to reduce osteoporosis by utilizing our knowledge on circadian regulation of bone. (c) 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
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收藏
页数：10
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