Desymmetrization of meso-diols by acylation with axially chiral twisted amides and its mechanistic studies

被引：17

作者：

Yamada, S ^{[1
]}

Katsumata, H ^{[1
]}

机构：

[1] Ochanomizu Univ, Fac Sci, Dept Chem, Bunkyo Ku, Tokyo 1128610, Japan

来源：

CHEMISTRY LETTERS | 1998年 / 10期

关键词：

D O I：

10.1246/cl.1998.995

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Desymmetrization of meso-1,2-, -1,3-, and -1,4-diols was performed by acylation with chiral twisted amides.(1) The conformation of the twisted amides was studied by optimization of the PM3 method in order to elucidate the reaction mechanism. The directionality of the amide bond rotation was considered to be significantly responsible for the stereoselectivity.

引用

页码：995 / 996

页数：2

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