The enantioselective construction of trifluoromethylated quaternary stereocenters via the Rh-catalyzed asymmetric dehydrated arylation of unprotected hemiaminals

被引：7
作者：
Sun, Yu-Tuo [1 ,2 ]
Zhu, Dong-Xing [1 ,2 ]
Rao, Xiaofeng [3 ,4 ]
Xu, Ming-Hua [1 ,2 ,3 ,4 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chongzhi Rd, Shanghai 201203, Peoples R China
[2] Univ Chinese Acad Sci, Sch Pharm, 555 Zu Chongzhi Rd, Shanghai 201203, Peoples R China
[3] Southern Univ Sci & Technol, Shenzhen Grubbs Inst, 1088 Xueyuan Blvd, Shenzhen 518055, Peoples R China
[4] Southern Univ Sci & Technol, Dept Chem, 1088 Xueyuan Blvd, Shenzhen 518055, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2020年 / 7卷 / 02期
基金：
中国国家自然科学基金;
关键词：
CHIRAL DIENE LIGANDS; OLEFIN LIGANDS; ORGANOBORON REAGENTS; KETIMINES SYNTHESIS; ARYLBORONIC ACIDS; PHOSPHITE-OLEFIN; SULFUR-OLEFINS; ACCESS; EFFICIENT; ACTIVATION;
D O I：
10.1039/c9qo01203f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method for the highly enantioselective Rh-catalyzed dehydrated arylation of unprotected hemiaminals has been developed, and provided a series of chiral benzosultams bearing trifluoromethylated quaternary stereocenters in high yields with excellent enantioselectivities (up to 99% ee). The synthetic utility was further demonstrated by the facile enantioselective construction of a HIV-1 inhibitor molecule.
引用
收藏
页码：340 / 344
页数：5
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