Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals

被引：467

作者：

Tarke, Alison ^{[1
,2
,3
]}

Sidney, John ^{[1
]}

Methot, Nils ^{[1
]}

Yu, Esther Dawen ^{[1
]}

Zhang, Yun ^{[5
]}

Dan, Jennifer M. ^{[1
,4
]}

Goodwin, Benjamin ^{[1
]}

Rubiro, Paul ^{[1
]}

Sutherland, Aaron ^{[1
]}

Wang, Eric ^{[1
]}

Frazier, April ^{[1
]}

Ramirez, Sydney I. ^{[1
,4
]}

Rawlings, Stephen A. ^{[4
]}

Smith, Davey M. ^{[4
]}

Antunes, Ricardo da Silva ^{[1
]}

Peters, Bjoern ^{[1
,4
]}

Scheuermann, Richard H. ^{[1
,5
,6
]}

Weiskopf, Daniela ^{[1
]}

Crotty, Shane ^{[1
,4
]}

Grifoni, Alba ^{[1
]}

Sette, Alessandro ^{[1
,4
]}

机构：

[1] La Jolla Inst Immunol LJI, Ctr Infect Dis & Vaccine Res, La Jolla, CA 92037 USA

[2] Univ Genoa, Dept Internal Med, I-16132 Genoa, Italy

[3] Univ Genoa, Ctr Excellence Biomed Res CEB, I-16132 Genoa, Italy

[4] Univ Calif San Diego UCSD, Div Infect Dis & Global Publ Hlth, Dept Med, La Jolla, CA 92037 USA

[5] J Craig Venter Inst, La Jolla, CA 92037 USA

[6] Univ Calif San Diego, Dept Pathol, San Diego, CA 92093 USA

来源：

CELL REPORTS MEDICINE | 2021年 / 2卷 / 07期

关键词：

RECEPTOR-BINDING DOMAIN; COVID-19; PROTECTION; MUTATIONS; EPITOPES; IMMUNITY; B.1.1.7;

D O I：

10.1016/j.xcrm.2021.100355

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The emergence of SARS-CoV-2 variants with evidence of antibody escape highlight the importance of addressing whether the total CD4(+) and CD8(+) T cell recognition is also affected. Here, we compare SARS-CoV-2-specific CD4+ and CD8(+) T cells against the B.1.1.7, B.1.351, P.1, and CAL.20C lineages in COVID-19 convalescents and in recipients of the Moderna (mRNA-1273) or Pfizer/BioNTech (BNT162b2) COVID-19 vaccines. The total reactivity against SARS-CoV-2 variants is similar in terms of magnitude and frequency of response, with decreases in the 10%-22% range observed in some assay/VOC combinations. A total of 7% and 3% of previously identified CD4(+) and CD8(+) T cell epitopes, respectively, are affected by mutations in the various VOCs. Thus, the SARS-CoV-2 variants analyzed here do not significantly disrupt the total SARSCoV-2 T cell reactivity; however, the decreases observed highlight the importance for active monitoring of T cell reactivity in the context of SARS-CoV-2 evolution.

引用

页数：17

共 79 条

[1] Early rate reductions of SARS-CoV-2 infection and COVID-19 in BNT162b2 vaccine recipients [J].

Amit, Sharon ;

Regev-Yochay, Gili ;

Afek, Arnon ;

Kreiss, Yitshak ;

Leshem, Eyal .

LANCET, 2021, 397 (10277) :875-877

[2]

Andreano Emanuele, 2020, bioRxiv, DOI 10.1101/2020.12.28.424451

[3] Immune history profoundly affects broadly protective B cell responses to influenza [J].

Andrews, Sarah F. ;

Huang, Yunping ;

Kaur, Kaval ;

Popova, Lyubov I. ;

Ho, Irvin Y. ;

Pauli, Noel T. ;

Dunand, Carole J. Henry ;

Taylor, William M. ;

Lim, Samuel ;

Huang, Min ;

Qu, Xinyan ;

Lee, Jane-Hwei ;

Salgado-Ferrer, Marlene ;

Krammer, Florian ;

Palese, Peter ;

Wrammert, Jens ;

Ahmed, Rafi ;

Wilson, Patrick C. .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (316)

[4] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[5] COVID-19 vaccine-readiness for anti-CD20-depleting therapy in autoimmune diseases [J].

Baker, D. ;

Roberts, C. A. K. ;

Pryce, G. ;

Kang, A. S. ;

Marta, M. ;

Reyes, S. ;

Schmierer, K. ;

Giovannoni, G. ;

Amor, S. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2020, 202 (02) :149-161

[6] SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19 [J].

Braun, Julian ;

Loyal, Lucie ;

Frentsch, Marco ;

Wendisch, Daniel ;

Georg, Philipp ;

Kurth, Florian ;

Hippenstiel, Stefan ;

Dingeldey, Manuela ;

Kruse, Beate ;

Fauchere, Florent ;

Baysal, Emre ;

Mangold, Maike ;

Henze, Larissa ;

Lauster, Roland ;

Mall, Marcus A. ;

Beyer, Kirsten ;

Roehmel, Jobst ;

Voigt, Sebastian ;

Schmitz, Juergen ;

Miltenyi, Stefan ;

Demuth, Ilja ;

Mueller, Marcel A. ;

Hocke, Andreas ;

Witzenrath, Martin ;

Suttorp, Norbert ;

Kern, Florian ;

Reimer, Ulf ;

Wenschuh, Holger ;

Drosten, Christian ;

Corman, Victor M. ;

Giesecke-Thiel, Claudia ;

Sander, Leif Erik ;

Thiel, Andreas .

NATURE, 2020, 587 (7833) :270-+

[7] Persistent cellular immunity to SARS-CoV-2 infection [J].

Breton, Gaelle ;

Mendoza, Pilar ;

Hagglof, Thomas ;

Oliveira, Thiago Y. ;

Schaefer-Babajew, Dennis ;

Gaebler, Christian ;

Turroja, Martina ;

Hurley, Arlene ;

Caskey, Marina ;

Nussenzweig, Michel C. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2021, 218 (04)

[8] Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma [J].

Cele, Sandile ;

Gazy, Inbal ;

Jackson, Laurelle ;

Hwa, Shi-Hsia ;

Tegally, Houriiyah ;

Lustig, Gila ;

Giandhari, Jennifer ;

Pillay, Sureshnee ;

Wilkinson, Eduan ;

Naidoo, Yeshnee ;

Karim, Farina ;

Ganga, Yashica ;

Khan, Khadija ;

Bernstein, Mallory ;

Balazs, Alejandro B. ;

Gosnell, Bernadett, I ;

Hanekom, Willem ;

Moosa, Mahomed-Yunus S. ;

Lessells, Richard J. ;

de Oliveira, Tulio ;

Sigal, Alex .

NATURE, 2021, 593 (7857) :142-+

[9] BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting [J].

Dagan, Noa ;

Barda, Noam ;

Kepten, Eldad ;

Miron, Oren ;

Perchik, Shay ;

Katz, Mark A. ;

Hernan, Miguel A. ;

Lipsitch, Marc ;

Reis, Ben ;

Balicer, Ran D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (15) :1412-1423

[10] Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection [J].

Dan, Jennifer M. ;

Mateus, Jose ;

Kato, Yu ;

Hastie, Kathryn M. ;

Yu, Esther Dawen ;

Faliti, Caterina E. ;

Grifoni, Alba ;

Ramirez, Sydney, I ;

Haupt, Sonya ;

Frazier, April ;

Nakao, Catherine ;

Rayaprolu, Vamseedhar ;

Rawlings, Stephen A. ;

Peters, Bjoern ;

Krammer, Florian ;

Simon, Viviana ;

Saphire, Erica Ollmann ;

Smith, Davey M. ;

Weiskopf, Daniela ;

Sette, Alessandro ;

Crotty, Shane .

SCIENCE, 2021, 371 (6529) :587-+

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