Virotherapy as a Potential Therapeutic Approach for the Treatment of Aggressive Thyroid Cancer

被引：14

作者：

Malfitano, Anna Maria ^{[1
]}

Di Somma, Sarah ^{[1
]}

Prevete, Nella ^{[1
]}

Portella, Giuseppe ^{[1
]}

机构：

[1] Univ Federico II Napoli, URT Genom Diabet Inst Expt Endocrinol & Oncol G S, Natl Council Res CNR, Dipartimento Sci Med Traslaz, I-80131 Naples, Italy

来源：

CANCERS | 2019年 / 11卷 / 10期

关键词：

oncolytic virus; immunotherapy; anaplastic and poorly differentiated thyroid carcinoma; ONCOLYTIC VACCINIA VIRUS; IMMUNOGENIC CELL-DEATH; IMMUNE CHECKPOINT BLOCKADE; IN-VITRO; OVARIAN-CANCER; DNA-DAMAGE; T-CELLS; CARCINOMA; ADENOVIRUS; REPLICATION;

D O I：

10.3390/cancers11101532

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Virotherapy is a novel cancer treatment based on oncolytic viruses (OVs), which selectively infect and lyse cancer cells, without harming normal cells or tissues. Several viruses, either naturally occurring or developed through genetic engineering, are currently under investigation in clinical studies. Emerging reports suggesting the immune-stimulatory property of OVs against tumor cells further support the clinical use of OVs for the treatment of lesions lacking effective therapies. Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC), have a poor prognosis and limited treatment options. Therefore, several groups investigated the therapeutic potential of OVs in PDTC/ATC models producing experimental data sustaining the potential clinical efficacy of OVs in these cancer models. Moreover, the presence of an immunosuppressive microenvironment further supports the potential use of OVs in ATC. In this review, we present the results of the studies evaluating the efficacy of OVs alone or in combination with other treatment options. In particular, their potential therapeutic combination with multiple kinases inhibitors (MKIs) or immune checkpoint inhibitors are discussed.

引用

页数：21

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