The role of pharmacokinetic and pharmacokinetic/pharmacodynamic modeling in drug discovery and development

被引：8
|
作者：
Yu, Xiang-Qing [1 ]
Wilson, Alan G. E. [1 ]
机构：
[1] Lexicon Pharmaceut Inc, Drug Metab Pharmacokinet Toxicol & Pathol, The Woodlands, TX 77381 USA
来源：
FUTURE MEDICINAL CHEMISTRY | 2010年 / 2卷 / 06期
关键词：
VITRO METABOLISM DATA; SYSTEMS BIOLOGY; PHASE-0; TRIALS; IN-SILICO; BIOMARKERS; PREDICTION; SIMULATION; PARAMETERS; PHARMACOLOGY; DISPOSITION;
D O I：
10.4155/FMC.10.181
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In silico and computational modeling, in conjunction with early absorption, distribution, metabolism and excretion/pharmacokinetic screening and pharmacokinetic/pharmacodyanmic modeling and simulation, will play an increasingly important role in optimizing drug discovery and development in the future.
引用
收藏
页码：923 / 928
页数：6
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