Tandem Facial Amphiphiles for Membrane Protein Stabilization

被引：81

作者：

Chae, Pil Seok ^{[1
]}

Gotfryd, Kamil ^{[2
]}

Pacyna, Jennifer ^{[3
]}

Miercke, Larry J. W. ^{[4
]}

Rasmussen, Soren G. F. ^{[5
]}

Robbins, Rebecca A. ^{[4
]}

Rana, Rohini R. ^{[3
]}

Loland, Claus J. ^{[2
]}

Kobilka, Brian ^{[5
]}

Stroud, Robert ^{[4
]}

Byrne, Bernadette ^{[3
]}

Gether, Ulrik ^{[2
]}

Gellman, Samuel H. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

[2] Univ Copenhagen, Dept Neurosci & Pharmacol, Fac Hlth Sci, DK-2200 Copenhagen, Denmark

[3] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England

[4] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA

[5] Stanford Univ, Stanford, CA 94305 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 47期

关键词：

DETERGENTS; STABILITY; BINDING;

D O I：

10.1021/ja1072959

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe a new type of synthetic amphiphile that is intended to support biochemical characterization of intrinsic membrane proteins. Members of this new family displayed favorable behavior with four of five membrane proteins tested, and these amphiphiles formed relatively small micelles.

引用

页码：16750 / 16752

页数：3

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[21] Conformational thermostabilization of the β1-adrenergic receptor in a detergent-resistant form [J].