The role of SLITRK6 in the pathogenesis of Tourette syndrome: From the conclusion of a family-based study in the Chinese Han population

被引：3

作者：

Liu, Wenmiao ^{[1
,2
]}

Zhang, Xuzhan ^{[3
]}

Deng, Ziwen ^{[4
]}

Li, Guixia ^{[3
]}

Zhang, Ru ^{[1
,2
]}

Yang, Zongjun ^{[5
]}

Che, Fengyuan ^{[6
]}

Liu, Shiguo ^{[1
,2
]}

Li, Hui ^{[4
]}

机构：

[1] Qingdao Univ, Med Genet Dept, Affiliated Hosp, Qingdao, Shandong, Peoples R China

[2] Qingdao Univ, Prenatal Diag Ctr, Affiliated Hosp, Qingdao 266000, Shandong, Peoples R China

[3] Heze Municipal Hosp, Dept Clin Lab, Heze, Shandong, Peoples R China

[4] Qingdao Univ, Dept Clin Lab, Affiliated Hosp, Qingdao 266000, Shandong, Peoples R China

[5] Women & Childrens Hosp Qingdao, Dept Clin Lab, Qingdao, Shandong, Peoples R China

[6] Shandong Univ, Dept Neurol, Affiliated Linyi Peoples Hosp, Linyi, Shandong, Peoples R China

来源：

JOURNAL OF GENE MEDICINE | 2020年 / 22卷 / 06期

基金：

中国国家自然科学基金;

关键词：

family-based association study; genetic susceptibility; single nucleotide polymorphisms; SLITRK6; gene; Tourette syndrome; PROTEIN FAMILY; MUTATIONS; VARIANTS;

D O I：

10.1002/jgm.3173

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Background Tourette syndrome (TS) is a complex neuropsychiatric disorder coupled with obvious genetic heterogeneity. Studies in recent years have confirmed the association of SLITRK genes with sensory and neuropsychiatric diseases. To detect whether SLITRK6 is involved in the progress of TS, a family-based association study was performed to explore the possible genetic association between SLITRK6 and TS in the Chinese Han population. Methods We genotyped 399 TS nuclear families trios, and then analyzed three tag SLITRK6 single nucleotide polymorphisms using the transmission disequilibrium test (TDT) haplotype relative risk (HRR) and haplotype-based haplotype relative risk (HHRR) methods. Results The TDT showed no statistically significant allele transfer for the three polymorphisms. The HRR and HHRR also showed a negative association. Conclusions Despite the results suggesting that these polymorphisms may not be associated with susceptibility to TS in the Chinese Han population, we are still unable to determine the potential role of SLITRK6 in the pathogenesis of TS. Furthermore, the results still need to be confirmed in a larger sample size and in different populations.

引用

页数：5