Mitochondria and apoptosis

被引：8081
作者：
Green, DR
Reed, JC
机构：
[1] La Jolla Inst Allergy & Immunol, San Diego, CA 92121 USA
[2] Burnham Inst, La Jolla, CA 92037 USA
来源：
SCIENCE | 1998年 / 281卷 / 5381期
关键词：
D O I：
10.1126/science.281.5381.1309
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins. The different signals that converge on mitochondria to trigger or inhibit these events and their downstream effects delineate several major pathways in physiological cell death.
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收藏
页码：1309 / 1312
页数：4
相关论文
共 56 条
[1]   Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome c during fas-mediated apoptosis [J].
Adachi, S ;
Cross, AR ;
Babior, BM ;
Gottlieb, RA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (35) :21878-21882
[2]   Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death [J].
Amarante-Mendes, GP ;
Finucane, DM ;
Martin, SJ ;
Cotter, TG ;
Salvesen, GS ;
Green, DR .
CELL DEATH AND DIFFERENTIATION, 1998, 5 (04) :298-306
[3]   Inhibition of Bax channel-forming activity by Bcl-2 [J].
Antonsson, B ;
Conti, F ;
Ciavatta, A ;
Montessuit, S ;
Lewis, S ;
Martinou, I ;
Bernasconi, L ;
Bernard, A ;
Mermod, JJ ;
Mazzei, G ;
Maundrell, K ;
Gambale, F ;
Sadoul, R ;
Martinou, JC .
SCIENCE, 1997, 277 (5324) :370-372
[4]  
BAFFY G, 1993, J BIOL CHEM, V268, P6511
[5]   RECENT PROGRESS ON REGULATION OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE - A CYCLOSPORINE-SENSITIVE PORE IN THE INNER MITOCHONDRIAL-MEMBRANE [J].
BERNARDI, P ;
BROEKEMEIER, KM ;
PFEIFFER, DR .
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1994, 26 (05) :509-517
[6]  
BLACKSTONE NW, 1995, EVOLUTION, V49, P785, DOI 10.1111/j.1558-5646.1995.tb02315.x
[7]   Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization [J].
Bossy-Wetzel, E ;
Newmeyer, DD ;
Green, DR .
EMBO JOURNAL, 1998, 17 (01) :37-49
[8]   Neural apoptosis [J].
Bredesen, DE .
ANNALS OF NEUROLOGY, 1995, 38 (06) :839-851
[9]   Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers [J].
Brunet, CL ;
Gunby, RH ;
Benson, RSP ;
Hickman, JA ;
Watson, AJM ;
Brady, G .
CELL DEATH AND DIFFERENTIATION, 1998, 5 (01) :107-115
[10]   Mitochondria and cells produce reactive oxygen species in virtual anaerobiosis: relevance to ceramide-induced apoptosis [J].
Degli Esposti, M ;
McLennan, H .
FEBS LETTERS, 1998, 430 (03) :338-342
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