The vessel wall: A forgotten player in post thrombotic syndrome

被引：42

作者：

DeRoo, Scott ^{[1
]}

Deatrick, K. Barry ^{[1
]}

Henke, Peter K. ^{[1
]}

机构：

[1] Univ Michigan, Dept Surg, Vasc Surg Sect, Ann Arbor, MI 48109 USA

来源：

THROMBOSIS AND HAEMOSTASIS | 2010年 / 104卷 / 04期

关键词：

Cell-matrix interactions; deep-vein thrombosis; inflammation; matrix metalloproteinases; SMOOTH-MUSCLE-CELLS; PLASMINOGEN-ACTIVATOR INHIBITOR-1; DEEP-VEIN-THROMBOSIS; FIBROBLAST-GROWTH-FACTOR; MONOCYTE CHEMOATTRACTANT PROTEIN-1; MOLECULAR-WEIGHT HEPARIN; MARROW-DERIVED CELLS; HUMAN SAPHENOUS-VEIN; EXPRESSION IN-VIVO; VENOUS THROMBOSIS;

D O I：

10.1160/TH10-03-0183

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Much research in venous thrombotic diseases focuses on the acute thrombotic process such as anticoagulation and risk factors. Deep-vein thrombosis directly leads to post thrombotic syndrome, and this can cause significant patient disability. Little research has focused on the vein wall injury response to the thrombotic inflammatory insult. Herein, we review what is currently known about this process with emphasis on the matrix, mediators, and vascular medial smooth muscle response after thrombotic injury. Translational therapies and potential future agents are reviewed.

引用

页码：681 / 692

页数：12

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