Harnessing the therapeutic potential of extracellular vesicles for cancer treatment

被引：15
作者：
Zhang, Ying [1 ,2 ,3 ]
Xiao, Yu [5 ]
Sun, Gaoge [1 ,2 ,3 ]
Jin, Xue [1 ,2 ,3 ,4 ]
Guo, Lerui [1 ,2 ,3 ]
Li, Tian [6 ]
Yin, Hang [1 ,2 ,3 ]
机构：
[1] Tsinghua Univ, Sch Pharmaceut Sci, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Beijing 100082, Peoples R China
[2] Tsinghua Univ, Tsinghua Univ Peking Univ Joint Ctr Life Sci, Beijing 100084, Peoples R China
[3] Tsinghua Univ, Ctr Struct Biol, Beijing Adv Innovat, Beijing, Peoples R China
[4] Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
[5] Southern Med Univ, Zhujiang Hosp, Lab Med Ctr, Guangzhou, Guangdong, Peoples R China
[6] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China
来源：
SEMINARS IN CANCER BIOLOGY | 2021年 / 74卷
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
Extracellular vesicle; Cancer treatment; Drug delivery; Immunotherapy; Clinical trials; CELL-DERIVED EXOSOMES; MESENCHYMAL STROMAL CELLS; BLOOD-BRAIN-BARRIER; ANTIGEN PRESENTATION; ANTITUMOR-ACTIVITY; MESSENGER-RNA; TUMOR-GROWTH; STEM-CELLS; IN-VITRO; DELIVERY;
D O I：
10.1016/j.semcancer.2021.05.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer therapeutic strategies include surgeries, radiotherapy, chemotherapy, targeted therapy and immuno-therapies. However, current cancer treatment still faces challenges such as postoperative residuals, postoperative recurrence, chemoradiotherapy resistance and lack of drugs with high specificity, due to the complexity of the cancer environment. Extracellular vesicles (EVs) are lipid-capsuled membrane vesicles secreted from cells, communicating vital messages between cells and regarding function in tumorigenesis and metastasis. Investi-gation of compositions and functions of EVs may open unprecedented, promising avenues for cancer thera-peutics. This review brings new perspectives from both researchers and clinicians in the EV field, emphasizing the ties between basic research and ongoing clinical trials. In sum, our review summarizes the roles EVs play in cancer therapy, ranging from mechanisms to applications in cancer treatment. In particular, it focuses on their therapeutic potential with an eye toward clinical relevance.
引用
收藏
页码：92 / 104
页数：13
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