Increased Fecal Neopterin Parallels Gastrointestinal Symptoms in COVID-19

被引：10

作者：

Grabherr, Felix ^{[1
]}

Effenberger, Maria ^{[1
]}

Pedrini, Alisa ^{[1
]}

Mayr, Lisa ^{[1
]}

Schwaerzler, Julian ^{[1
]}

Reider, Simon ^{[1
]}

Enrich, Barbara ^{[1
]}

Fritsche, Gernot ^{[2
]}

Wildner, Sophie ^{[2
]}

Bellmann-Weiler, Rosa ^{[2
]}

Weiss, Guenter ^{[2
]}

Scholl-Buergi, Sabine ^{[3
]}

Mueller, Thomas ^{[3
]}

Moschen, Alexander ^{[1
]}

Adolph, Timon E. ^{[1
]}

Tilg, Herbert ^{[1
]}

机构：

[1] Med Univ Innsbruck, Dept Internal Med Gastroenterol Hepatol Endocrino, Innsbruck, Austria

[2] Med Univ Innsbruck, Dept Internal Med Infect Dis Pulmonol & Rheumatol, Innsbruck, Austria

[3] Med Univ Innsbruck, Dept Pediat 1, Innsbruck, Austria

来源：

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY | 2021年 / 12卷 / 01期

基金：

奥地利科学基金会;

关键词：

DISEASE-ACTIVITY;

D O I：

10.14309/ctg.0000000000000293

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

INTRODUCTION: Coronavirus disease (COVID-19) has spread from Wuhan, China, and become a worldwide pandemic. Most patients display respiratory symptoms but up to 50% report gastrointestinal symptoms. Neopterin is a surrogate marker for viral inflammation, and its production by macrophages is driven by interferon-gamma. METHODS: We measured fecal neopterin in 37 hospitalized COVID-19 patients not requiring intensive care measures and 22 healthy controls. RESULTS: Fecal neopterin was elevated in stool samples from COVID-19 patients compared with that in samples from healthy controls. Especially, patients reporting gastrointestinal symptoms exhibited increased fecal neopterin values. DISCUSSION: COVID-19 is associated with an inflammatory immune response in the gastrointestinal tract.

引用

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