SYNTHESIS AND BIOLOGICAL SCREENING OF SOME NEW 1,5-BENZODIAZEPINE DERIVATIVES AS PROMISING ANTIBACTERIAL AND ANTITUBERCULAR AGENTS

被引：0

作者：

Singh, Gurpreet ^{[1
]}

Nayak, Surendra Kumar ^{[2
]}

Monga, Vikramdeep ^{[1
]}

机构：

[1] Rajendra Inst Technol & Sci, Dept Pharmaceut Chem, Sirsa, Haryana, India

[2] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara, Punjab, India

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 27卷 / 02期

关键词：

1,5-Benzodiazepines; Chalcones; Antibacterial; Antitubercular; MICROWAVE-ASSISTED SYNTHESIS; ANTIBIOTIC-RESISTANCE; ANTIMICROBIAL AGENTS; EFFICIENT SYNTHESIS; CHALCONES; ACID;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, various substituted 1,5-benzodiazepines were synthesized by condensing different substituted chalcones with o-phenylenediamine in methanol using piperidine as a base under refluxing conditions and were obtained in good yield after purification. The final compounds (5a-5h) were structurally elucidated and evaluated in vitro for antibacterial activity against five human pathogenic bacterial strains using disc diffusion method and for antitubercular activity using microplate Alamar Blue assay method. Results of antimicrobial evaluation data showed that some of the newly synthesized compounds exhibited potent antibacterial and antitubercular activity. [GRAPHICS]

引用

页码：143 / 149

页数：7

共 50 条

[31] One pot solvent-free synthesis of 1,5-benzodiazepine derivatives
Langade, M., 1600, Journal of Chemical and Pharmaceutical Research, 3/668 Malviya Nagar, Jaipur, Rajasthan, India (05):
[32] Ytterbium Perfluorooctanesulfonate catalyzed synthesis of 1,5-benzodiazepine derivatives in fluorous solvents
Yi, Wen-Bin
Cai, Chun
SYNTHETIC COMMUNICATIONS, 2007, 37 (19-21) : 3827 - 3833
[33] Efficient and green method for the synthesis of 1,5-benzodiazepine and quinoxaline derivatives in water
Hazarika, Parasa
Gogoi, Pranjal
Konwar, Dilip
SYNTHETIC COMMUNICATIONS, 2007, 37 (19-21) : 3447 - 3454
[34] An expeditious synthesis of 1,5-benzodiazepine derivatives catalyzed by CdCl2
Pasha, M. A.
Jayashankara, V. P.
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2006, 45 (12): : 2716 - 2719
[35] NbCl5 as an Efficient Catalyst for the Synthesis of 1,5-Benzodiazepine Derivatives
Gao, Shu-Tao
Liu, Wei-Hua
Ma, Jing-Jun
Wang, Chun
Liang, Qian
SYNTHETIC COMMUNICATIONS, 2009, 39 (18) : 3278 - 3284
[36] An expeditious synthesis of 1,5-benzodiazepine derivatives catalysed by zinc acetate dihydrate
Pasha, M. A.
Jayashankara, V. P.
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2006, 15 (04) : 397 - 398
[37] Synthesis of 1H-1,5-Benzodiazepine derivatives and pyridinylquinoxalines with heterocyclic ketones
Jung, Dai-il
Song, Ju-hyun
Kim, Yong-hwan
Lee, Do-hun
Lee, Yong-gyun
Park, Yu-mi
Choi, Soon-kyu
Hahnt, Jung-tai
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2007, 28 (10) : 1877 - 1880
[38] p-nitrobenzoic acid promoted synthesis of 1,5-benzodiazepine derivatives
Varala, Ravi
Enugala, Ramu
Adapa, Srinivas R.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2007, 18 (02) : 291 - 296
[39] Zirconium(IV) chloride-catalyzed synthesis of 1,5-benzodiazepine derivatives
Reddy, K. Srinivasa
Reddy, Ch. Venkateshwar
Mahesh, M.
Reddy, K. Rosi
Raju, P. V. K.
Reddy, V. V. Narayana
CANADIAN JOURNAL OF CHEMISTRY, 2007, 85 (03) : 184 - 188
[40] Circular Dichroism Studies on New Optically Active 1,5-Benzodiazepine Derivatives
Khan, K. M.
Malik, F.
Hasan, M.
Perveen, S.
Zeitschrift fuer Naturforschung. B, Journal of Chemical Sciences, 51 (04):

← 1 2 3 4 5 →