SYNTHESIS AND BIOLOGICAL SCREENING OF SOME NEW 1,5-BENZODIAZEPINE DERIVATIVES AS PROMISING ANTIBACTERIAL AND ANTITUBERCULAR AGENTS

被引：0
|
作者：
Singh, Gurpreet [1 ]
Nayak, Surendra Kumar [2 ]
Monga, Vikramdeep [1 ]
机构：
[1] Rajendra Inst Technol & Sci, Dept Pharmaceut Chem, Sirsa, Haryana, India
[2] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara, Punjab, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2017年 / 27卷 / 02期
关键词：
1,5-Benzodiazepines; Chalcones; Antibacterial; Antitubercular; MICROWAVE-ASSISTED SYNTHESIS; ANTIBIOTIC-RESISTANCE; ANTIMICROBIAL AGENTS; EFFICIENT SYNTHESIS; CHALCONES; ACID;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this study, various substituted 1,5-benzodiazepines were synthesized by condensing different substituted chalcones with o-phenylenediamine in methanol using piperidine as a base under refluxing conditions and were obtained in good yield after purification. The final compounds (5a-5h) were structurally elucidated and evaluated in vitro for antibacterial activity against five human pathogenic bacterial strains using disc diffusion method and for antitubercular activity using microplate Alamar Blue assay method. Results of antimicrobial evaluation data showed that some of the newly synthesized compounds exhibited potent antibacterial and antitubercular activity. [GRAPHICS]
引用
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页码：143 / 149
页数：7
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