Phosphatidylcholine attenuated docetaxel-induced peripheral neurotoxicity in rats

被引：21

作者：

Kim, Sung Tae ^{[1
]}

Kyung, Eun Jung ^{[1
]}

Suh, Jung Sook ^{[3
]}

Lee, Ho Sung ^{[1
]}

Lee, Jun Ho ^{[1
]}

Chae, Soo In ^{[1
]}

Park, Eon Sub ^{[2
]}

Chung, Yoon Hee ^{[4
]}

Bae, Jinhyung ^{[3
]}

Lee, Tae Jin ^{[2
]}

Lee, Won Mo ^{[3
]}

Sohn, Uy Dong ^{[3
]}

Jeong, Ji Hoon ^{[1
]}

机构：

[1] Chung Ang Univ, Dept Pharmacol, Coll Med, Seoul, South Korea

[2] Chung Ang Univ, Dept Pathol, Coll Med, Seoul, South Korea

[3] Chung Ang Univ, Dept Pharmacol, Coll Pharm, Seoul, South Korea

[4] Chung Ang Univ, Dept Anat, Coll Med, Seoul, South Korea

来源：

DRUG AND CHEMICAL TOXICOLOGY | 2018年 / 41卷 / 04期

关键词：

Antioxidant; docetaxel; oxidative stress; peripheral neurotoxicity; phosphatidylcholine; OXALIPLATIN-INDUCED NEUROPATHY; INDUCED OXIDATIVE STRESS; PHASE-II; CHEMOTHERAPY; MARKER; MALONDIALDEHYDE; NITROTYROSINE; PACLITAXEL; MODELS; SYSTEM;

D O I：

10.1080/01480545.2017.1390580

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Docetaxel is a taxane chemotherapeutic agent used in the treatment of breast cancer, prostate cancer and gastric cancer, but several side effects such as peripheral neurotoxicity could occur. The present study was designed to investigate the therapeutic potential of phosphatidylcholine (PC) on docetaxel-induced peripheral neurotoxicity. Rats were randomly divided into three groups and treated for 4 weeks. Behavioral tests were conducted to measure the effects of PC on docetaxel-induced decreases in mechanical & thermal nociceptive threshold. Biochemical tests were conducted to measure the level of oxidative stress on sciatic nerve. Histopathological and immunohistochemical experiments were also conducted to assess neuronal damage and glial activation. PC treatment significantly attenuated docetaxel-induced changes in mechanical & thermal nociceptive response latencies. PC decreased oxidative stress in sciatic nerve by increasing antioxidant levels (glutathione, glutathione peroxidase and superoxide dismutase activity). In immunohistochemical evaluation, PC treatment ameliorated docetaxel-induced neuronal damage and microglial activation in the sciatic nerve and spinal cord. Thus, PC showed protective effects against docetaxel-induced peripheral neurotoxicity. These effects may be attributed to its antioxidant properties and modulation of microglia.

引用

页码：476 / 485

页数：10

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