Multiple functions of junctin and junctate, two distinct isoforms of aspartyl beta-hydroxylase

被引：20
作者：
Hong, Chang-Soo
Kwon, Soon-Jae
Kim, Do Han
机构：
[1] Gwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea
[2] Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 362卷 / 01期
关键词：
Ryanodine receptor; calsequestrin; triadin; striated muscle; excitation-con traction coupling; calcium signaling; MICE OVEREXPRESSING JUNCTIN; CALCIUM-BINDING PROTEIN; J-J LOCUS; SARCOPLASMIC-RETICULUM; TRANSGENIC MICE; CARDIAC CALSEQUESTRIN; IMPAIRED RELAXATION; RYANODINE RECEPTOR; MOLECULAR-CLONING; CDNA CLONING;
D O I：
10.1016/j.bbrc.2007.07.166
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The single genomic locus, A beta H-J-J, encodes three functionally distinct proteins aspartyl beta-hydroxylase, junctin and junctate by alternative splicing. Among these three proteins, junctin and junctate could play important roles in the regulation of intracellular Ca2+ by regulating either Ca2+ release from intracellular Ca2+ stores or Ca2+ influx in various biological processes. Here we review recent findings concerning the expressional regulations and the proposed functions of junctin and junctate. (c) 2007 Elsevier Inc. All rights reserved.
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页码：1 / 4
页数：4
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