Oppositinines A and B: New Vasorelaxant β-Carboline Alkaloids from Neisosperma oppositifolia

被引：7

作者：

Ahmad, Kartini ^{[2
]}

Thomas, Noel F. ^{[1
]}

Hadi, A. Hamid A. ^{[1
]}

Mukhtar, Mat Ropi ^{[1
]}

Mohamad, Khalit ^{[3
]}

Nafiah, Mohd Azlan ^{[2
]}

Takeya, Koichi ^{[4
]}

Morita, Hiroshi ^{[5
]}

Litaudon, Marc ^{[6
]}

Arai, Hiroko ^{[5
]}

Awang, Khalijah ^{[1
]}

机构：

[1] Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 50603, Malaysia

[2] Univ Pendidikan Sultan Idris, Fac Sci & Technol, Dept Chem, Tanjong Malim 35900, Perak, Malaysia

[3] Univ Malaya, Fac Med, Dept Pharm, Kuala Lumpur 50603, Malaysia

[4] Tokyo Univ Pharm & Life Sci, Tokyo 1920392, Japan

[5] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan

[6] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 08期

关键词：

beta-carboline; indole; Neisosperma oppositifolia; Apocynaceae; vasorelaxant activity; KOPSIA-SINGAPURENSIS; STEM-BARK; APOCYNACEAE; RHAZINILAM;

D O I：

10.1248/cpb.58.1085

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new beta-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxindole. Structural elucidation of 1 and 2 was performed using 21) NMR methods. Oppositinines A (1) and B (2) showed potent vasorelaxant effects on the rat aorta.

引用

页码：1085 / 1087

页数：3

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