Improved synthesis of the iodine-free thyromimetic GC-1

被引:33
作者
Chiellini, G
Nguyen, NH
Yoshihara, HAI
Scanlan, TS [1 ]
机构
[1] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA
关键词
D O I
10.1016/S0960-894X(00)00531-X
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Synthesis of the TR beta -selective thyromimetic GC-1 has been improved using methoxymethyl (MOM) and triisopropylsilyl (TiPS) substituents as phenolic protecting groups. The new synthetic route is adaptable to analogue design. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2607 / 2611
页数:5
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