Peptide-Mediated Blood-Brain Barrier Transport of Polymersomes

被引：90

作者：

Georgieva, Julia V. ^{[2
]}

Brinkhuis, Rene P. ^{[1
]}

Stojanov, Katica ^{[2
]}

Weijers, Carel A. G. M. ^{[3
,4
]}

Zuilhof, Han ^{[3
,4
]}

Rutjes, Floris P. J. T. ^{[1
]}

Hoekstra, Dick ^{[2
]}

van Hest, Jan C. M. ^{[1
]}

Zuhorn, Inge S. ^{[2
]}

机构：

[1] Radboud Univ Nijmegen, Inst Mol & Mat, NL-6525 AJ Nijmegen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Sect Membrane Biol, Dept Cell Biol, NL-9713 AV Groningen, Netherlands

[3] Wageningen Univ, Organ Chem Lab, NL-6703 HB Wageningen, Netherlands

[4] King Abdulaziz Univ, Dept Chem & Mat Engn, Jeddah 21413, Saudi Arabia

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 33期

关键词：

bioorganic chemistry; blood-brain barrier; drug delivery; peptides; polymersomes; IN-VIVO; BIODEGRADABLE POLYMERSOMES; NERVOUS-SYSTEM; DELIVERY; NANOPARTICLES; THERAPEUTICS; VESICLES; PROTEIN; MOUSE;

D O I：

10.1002/anie.201202001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood-brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood-brain barrier transport is unprecedented. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8339 / 8342

页数：4

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