Optimizing the Laboratory Diagnosis of Clostridium difficile Infection

被引：16

作者：

Gilligan, Peter H. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Sch Med, UNC Hlth Care, Clin Microbiol Immunol Labs,Microbiol Immunol, Chapel Hill, NC 27516 USA

[2] Univ N Carolina, Sch Med, Pathol Lab Med, Chapel Hill, NC 27516 USA

来源：

CLINICS IN LABORATORY MEDICINE | 2015年 / 35卷 / 02期

关键词：

Clostridium difficile; Glutamate dehydrogenase; Algorithm; Diarrhea; Nucleic acid amplification test (NAAT); Toxin; Microbiome; Disease outcomes; POLYMERASE-CHAIN-REACTION; FECAL MICROBIOTA TRANSPLANTATION; TOXIN-B; STOOL SAMPLES; RISK-FACTORS; ALGORITHM; DISEASE; RATES; ASSAY; METAANALYSIS;

D O I：

10.1016/j.cll.2015.02.003

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The best laboratory diagnostic approach to detect Clostridium difficile infection (ODD is the subject of ongoing debate. In the United States, nucleic acid amplification tests (NAAT) have become the most widely used tests for making this diagnosis. Detection of toxin in stool may be a better predictor of CDI disease and severity. Laboratories that have switched from toxin-based to NAAT-based methods have significantly higher CD! detection rates. The important issue is whether all NAAT-positive patients have CDI or at least some of those patients are excretors of the organism and do not have clinical disease.

引用

页码：299 / +

页数：15

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