Manganese enhanced MRI (MEMRI): neurophysiological applications

被引：62

作者：

Inoue, Taeko ^{[1
]}

Majid, Tabassum ^{[2
]}

Pautler, Robia G. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA

[2] Baylor Coll Med, Translat Biol & Mol Med TBMM Grad Program, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Radiol, Houston, TX 77030 USA

[5] Baylor Coll Med, Huffington Ctr Aging, Houston, TX 77030 USA

来源：

REVIEWS IN THE NEUROSCIENCES | 2011年 / 22卷 / 06期

关键词：

axonal transport; imaging; manganese; MEMRI; mouse models; MRI; neuronal activity; neurophysiology; NUCLEAR-MAGNETIC-RESONANCE; IN-VIVO; AXONAL-TRANSPORT; DEPENDENT CONTRAST; BRAIN ACTIVATION; RAT; MOUSE; MICE; PATHWAY; CELLS;

D O I：

10.1515/RNS.2011.048

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Manganese ion (Mn2+) is a calcium (Ca2+) analog that can enter neurons and other excitable cells through voltage gated Ca2+ channels. Mn2+ is also a paramagnetic that shortens the spin-lattice relaxation time constant (T-1) of tissues where it has accumulated, resulting in positive contrast enhancement. Mn2+ was first investigated as a magnetic resonance imaging (MRI) contrast agent approximately 20 years ago to assess the toxicity of the metal in rats. In the late 1990s, Alan Koretsky and colleagues pioneered the use of manganese enhanced MRI (MEMRI) towards studying brain activity, tract tracing and enhancing anatomical detail. This review will describe the methodologies and applications of MEMRI in the following areas: monitoring brain activity in animal models, in vivo neuronal tract tracing and using MEMRI to assess in vivo axonal transport rates.

引用

页码：675 / 694

页数：20

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