Bone Mineral Density, Osteocalcin, and Bone-specific Alkaline Phosphatase in Patients with Insulin-dependent Diabetes Mellitus

被引：51

作者：

Lumachi, Franco ^{[1
]}

Camozzi, Valentina ^{[2
]}

Tombolan, Valeria

Luisetto, Giovanni ^{[2
]}

机构：

[1] Univ Padua, Sch Med, Dept Surg & Gastroenterol Sci, I-35128 Padua, Italy

[2] Univ Padua, Div Endocrinol, Dept Med & Surg Sci, I-35128 Padua, Italy

来源：

INTEGRATIVE PHYSIOLOGY | 2009年 / 1173卷 / S1期

关键词：

alkaline phosphatase; bone mineral density; diabetes mellitus; osteocalcin; osteodensitometry; osteopenia; PRIMARY HYPERPARATHYROIDISM; BIOCHEMICAL MARKERS; TURNOVER; OSTEOPENIA; FRACTURE; WOMEN;

D O I：

10.1111/j.1749-6632.2009.04955.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The aims of this study were to evaluate the prevalence of osteopenia and the relationships between osteocalcin (OC), bone alkaline phosphatase (bALP), and bone mineral density (BMD) in patients with insulin-dependent diabetes mellitus (IDDM). A group of 18 patients (median age 47, range 36-51) with uncomplicated IDDM (Group A) were matched by sex, age, and body mass index with 21 healthy control volunteers (Group B). All subjects underwent osteodensitometry with measurement of BMD at the lumbar spine and femoral neck. Osteopenia was present in 11 (61.1%) and 2 (9.5%) of Group A and B patients (P = 0.01), respectively. Both OC (28.4 +/- 16.4 versus 41.2 +/- 14.6 ng/mL; P = 0.005) and bALP (51.3 +/- 11.8 versus 61.7 +/- 10.6 U/L; P = 0.006) serum levels were significantly lower in patients with IDDM. BMD did not correlate with either OC or bALP. In conclusion, osteopenia is common among patients with IDDM, but the relationship between bone formation markers and BMD is still unclear.

引用

页码：E64 / E67

页数：4

共 20 条

[1]

Becker Carolyn, 2006, Clin Cornerstone, V8, P19, DOI 10.1016/S1098-3597(06)80062-1

[2] Molecular basis and clinical application of biological markers of bone turnover [J].

Calvo, MS ;

Eyre, DR ;

Gundberg, CM .

ENDOCRINE REVIEWS, 1996, 17 (04) :333-368

[3] Phalangeal quantitative ultrasound technology and dual energy X-ray densitometry in patients with primary hyperparathyroidism: influence of sex and menopausal status [J].

Camozzi, V ;

Lumachi, F ;

Mantero, F ;

Piccolo, M ;

Luisetto, G .

OSTEOPOROSIS INTERNATIONAL, 2003, 14 (07) :602-608

[4] A 55-year-old woman with osteopenia [J].

Cummings, Steven R. ;

Reynolds .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 296 (21) :2601-2610

[5]

Delmas PD, 2000, OSTEOPOROSIS INT, V11, P2, DOI 10.1007/s001980070002

[6] Osteopenia: a bone disorder associated with diabetes mellitus [J].

Duarte, VMG ;

Ramos, AMO ;

Rezende, LA ;

Macedo, UBO ;

Brandao-Neto, J ;

Almeida, MG ;

Rezende, AA .

JOURNAL OF BONE AND MINERAL METABOLISM, 2005, 23 (01) :58-68

[7] Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice [J].

Ferron, Mathieu ;

Hinoi, Eiichi ;

Karsenty, Gerard ;

Ducy, Patricia .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (13) :5266-5270

[8]

Garnero P, 1996, J BONE MINER RES, V11, P1531

[9]

Gunczler P, 1998, J PEDIATR ENDOCR MET, V11, P413

[10] Patterns of osteocalcin and bone specific alkaline phosphatase by age, gender, and race or ethnicity [J].

Gundberg, CM ;

Looker, AC ;

Nieman, SD ;

Calvo, MS .

BONE, 2002, 31 (06) :703-708

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