Ultrasound-responsive lipid microbubbles for drug delivery: A review of preparation techniques to optimise formulation size, stability and drug loading

被引：54

作者：

Al-Jawadi, Sana ^{[1
]}

Thakur, Sachin S. ^{[1
]}

机构：

[1] Univ Auckland, Sch Pharm, Fac Med & Hlth Sci, Private Bag 92019, Auckland 1142, New Zealand

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2020年 / 585卷

关键词：

Phospholipid microbubbles; Ultrasound contrast agents; Drug loading; Formulation strategies; Size standardisation; Stability; CONTRAST AGENTS; GENE DELIVERY; LOADED MICROBUBBLES; SURFACE-CHARGE; MEDIATED GENE; THERAPY; OXYGEN; DESTRUCTION; RELEASE; CANCER;

D O I：

10.1016/j.ijpharm.2020.119559

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lipid -shelled microbubbles have received extensive interest to enhance ultrasound -responsive drug delivery outcomes due to their high biocompatibility. While therapeutic effectiveness of microbubbles is well established, there remain limitations in sample homogeneity, stability profile and drug loading properties which restrict these formulations from seeing widespread use in the clinical setting. In this review, we evaluate and discuss the most encouraging leads in lipid microbubble design and optimisation. We examine current applications in drug delivery for the systems and subsequently detail shell compositions and preparation strategies that improve monodispersity while retaining ultrasound responsiveness. We review how excipients and storage techniques help maximise stability and introduce different characterisation and drug loading techniques and evaluate their impact on formulation performance. The review concludes with current quality control measures in place to ensure lipid microbubbles can be reproducibly used in drug delivery.

引用

页数：13

共 147 条

[1] Molecular Effects of Glycerol on Lipid Monolayers at the Gas Liquid Interface: Impact on Microbubble Physical and Mechanical Properties [J].